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. 1993 Jul;92(1):2. doi: 10.1172/JCI116550

When sugar is not so sweet: glucose toxicity.

A E Boyd 3rd, L G Moss
PMCID: PMC293513  PMID: 8325985

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boam D. S., Clark A. R., Docherty K. Positive and negative regulation of the human insulin gene by multiple trans-acting factors. J Biol Chem. 1990 May 15;265(14):8285–8296. [PubMed] [Google Scholar]
  2. Eizirik D. L., Korbutt G. S., Hellerström C. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function. J Clin Invest. 1992 Oct;90(4):1263–1268. doi: 10.1172/JCI115989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. German M. S., Moss L. G., Rutter W. J. Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures. J Biol Chem. 1990 Dec 25;265(36):22063–22066. [PubMed] [Google Scholar]
  4. Leahy J. L., Bonner-Weir S., Weir G. C. Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion. Diabetes Care. 1992 Mar;15(3):442–455. doi: 10.2337/diacare.15.3.442. [DOI] [PubMed] [Google Scholar]
  5. Olson L. K., Redmon J. B., Towle H. C., Robertson R. P. Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein. J Clin Invest. 1993 Jul;92(1):514–519. doi: 10.1172/JCI116596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Robertson R. P., Zhang H. J., Pyzdrowski K. L., Walseth T. F. Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. J Clin Invest. 1992 Aug;90(2):320–325. doi: 10.1172/JCI115865. [DOI] [PMC free article] [PubMed] [Google Scholar]

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