Fig. 1.

Scoring and comparison of sequence-profile matches. (A) Histograms show tails of distributions of proteomic scores for the p-loop prototype (red) and for the same prototype, but with the reshuffled positions (blue) where the functional signature is destroyed, while the amino acid composition of the profile is preserved. Inset shows quantile–quantile plot of complete distributions. (B) Selected matches (28 of 689) of the p-loop prototype (shown as logo). Numbers indicate identity to the consensus sequence (shown below). Sequence label is Genbank description of the protein from which these matches were taken. (C) Histogram shows pair-wise sequence identity of all the significant matches of the p-loop prototype.