Abstract
Strains of Salmonella typhimurium which are unable to synthesize their normal iron transport agent, enterobactin, and which must be supported with an exogenous chelator (siderophore) on certain media, were used to examine various types of wood for the presence of chelators. Western red cedar wood, Thuja plicata, was observed to contain large amounts of three substances that in low concentration would serve as chelators for S. typhimurium. The chelators from T. plicata were characterized and found to be alpha-, beta-, and gamma-thujaplicin. Other planar cyclic alpha-hydroxyketones were examined, and several were found to function as chelators for S. typhimurium.
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- Atkin C. L., Neilands J. B. Rhodotorulic acid, a diketopiperazine dihydroxamic acid with growth-factor activity. I. Isolation and characterization. Biochemistry. 1968 Oct;7(10):3734–3739. doi: 10.1021/bi00850a054. [DOI] [PubMed] [Google Scholar]
- Coombs R. W., Trust T. J. The effect of light on the antibacterial activity of beta-thujaplicin. Can J Microbiol. 1973 Sep;19(9):1177–1180. doi: 10.1139/m73-190. [DOI] [PubMed] [Google Scholar]
- Hollifield W. C., Jr, Neilands J. B. Ferric enterobactin transport system in Escherichia coli K-12. Extraction, assay, and specificity of the outer membrane receptor. Biochemistry. 1978 May 16;17(10):1922–1928. doi: 10.1021/bi00603a019. [DOI] [PubMed] [Google Scholar]
- Llinás M., Wilson D. M., Neilands J. B. Effect of metal binding on the conformation of enterobactin. A proton and carbon-13 nuclear magnetic resonance study. Biochemistry. 1973 Sep 25;12(20):3836–3843. doi: 10.1021/bi00744a007. [DOI] [PubMed] [Google Scholar]
- Luckey M., Pollack J. R., Wayne R., Ames B. N., Neilands J. B. Iron uptake in Salmonella typhimurium: utilization of exogenous siderochromes as iron carriers. J Bacteriol. 1972 Sep;111(3):731–738. doi: 10.1128/jb.111.3.731-738.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Norton S. J., Sanders E. DL-4,5-dihydroxy-2-pyridylalanine, an analog of 3,4-dihydroxyphenylalanine. J Med Chem. 1967 Sep;10(5):961–963. doi: 10.1021/jm00317a053. [DOI] [PubMed] [Google Scholar]
- O'Brien I. G., Gibson F. The structure of enterochelin and related 2,3-dihydroxy-N-benzoylserine conjugates from Escherichia coli. Biochim Biophys Acta. 1970 Aug 14;215(2):393–402. doi: 10.1016/0304-4165(70)90038-3. [DOI] [PubMed] [Google Scholar]
- Pollack J. R., Ames B. N., Neilands J. B. Iron transport in Salmonella typhimurium: mutants blocked in the biosynthesis of enterobactin. J Bacteriol. 1970 Nov;104(2):635–639. doi: 10.1128/jb.104.2.635-639.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pollack J. R., Neilands J. B. Enterobactin, an iron transport compound from Salmonella typhimurium. Biochem Biophys Res Commun. 1970 Mar 12;38(5):989–992. doi: 10.1016/0006-291x(70)90819-3. [DOI] [PubMed] [Google Scholar]
- Rennhard H. H. The metabolism of ethyl maltol and maltol in the dog. J Agric Food Chem. 1971 Jan-Feb;19(1):152–154. doi: 10.1021/jf60173a036. [DOI] [PubMed] [Google Scholar]
- Scott A. I., Guilford H., Lee E. Biosynthesis of the fungal tropolones. Stipitatic and stipitatonic acids. J Am Chem Soc. 1971 Jul 14;93(14):3534–3536. doi: 10.1021/ja00743a044. [DOI] [PubMed] [Google Scholar]
- Trust T. J., Coombs R. W. Antibacterial activity of beta-thujaplicin. Can J Microbiol. 1973 Nov;19(11):1341–1346. doi: 10.1139/m73-216. [DOI] [PubMed] [Google Scholar]