Skip to main content
NCBI home page
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1980 Jan;141(1):417–421. doi: 10.1128/jb.141.1.417-421.1980

Cysteine transport and sulfite reductase activity in a germination-defective mutant of Histoplasma capsulatum.

D H Howard, N Dabrowa, V Otto, J Rhodes
PMCID: PMC293617  PMID: 7354005

Abstract

A mutant of the dimorphic, zoopathogenic fungus Histoplasma capsulatum, defective in the ability of its blastospores to germinate, was used to show that the nutritional requirement for cysteine and the expression of sulfite reductase activity are temperature dependent and not related to the growth form the fungus, whereas the kinetics of cysteine transport depend on both temperature and the form of the fungus.

Full text

PDF
417

Images in this article

419Image
on p.419

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bawdon R. E., Garrison R. G. The uptake and incorporation of leucine and cystine by the mycelial and yeastlike phases of Blastomyces dermatitidis. Mycopathol Mycol Appl. 1974 Dec 18;54(4):421–433. doi: 10.1007/BF02050048. [DOI] [PubMed] [Google Scholar]
  2. Boguslawski G., Akagi J. M., Ward L. G. Possible role for cysteine biosynthesis in conversion from mycelial to yeast form of Histoplasma capsulatum. Nature. 1976 May 27;261(5558):336–338. doi: 10.1038/261336a0. [DOI] [PubMed] [Google Scholar]
  3. CATCHESIDE D. G. Isolation of nutritional mutants of Neurospora crassa by filtration enrichment. J Gen Microbiol. 1954 Aug;11(1):34–36. doi: 10.1099/00221287-11-1-34. [DOI] [PubMed] [Google Scholar]
  4. Conant N. F. Cultural Study of the Life-Cycle of Histoplasma capsulatum Darling 1906. J Bacteriol. 1941 May;41(5):563–579. doi: 10.1128/jb.41.5.563-579.1941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gilbert B. E., Howard D. H. Uptake of Cystine by the Yeast Phase of Histoplasma capsulatum. Infect Immun. 1970 Aug;2(2):139–144. doi: 10.1128/iai.2.2.139-144.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gupta R. K., Howard D. H. Comparative physiologial studies of the yeast and mycelial forms of Histoplasma capsulaum: uptake and incorporation of L-leucine. J Bacteriol. 1971 Mar;105(3):690–700. doi: 10.1128/jb.105.3.690-700.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HOWARD D. H. The morphogenesis of the parasitic forms of dimorphic fungi. A review. Mycopathol Mycol Appl. 1962 Oct 10;18:127–139. doi: 10.1007/BF02055153. [DOI] [PubMed] [Google Scholar]
  8. Howard D. H., Dabrowa N. Mutants of Arthroderma benhamiae. Sabouraudia. 1979 Mar;17(1):35–50. [PubMed] [Google Scholar]
  9. Howard D. H. Effect of temperature on the intracellular growth of Histoplasma capsulatum. J Bacteriol. 1967 Jan;93(1):438–444. doi: 10.1128/jb.93.1.438-444.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  11. Maresca B., Jacobson E., Medoff G., Kobayashi G. Cystine reductase in the dimorphic fungus Histoplasma capsulatum. J Bacteriol. 1978 Sep;135(3):987–992. doi: 10.1128/jb.135.3.987-992.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McVeigh I., Morton K. Nutritional studies of Histoplasma capsulatum. Mycopathol Mycol Appl. 1965 Apr 14;25(3):294–308. doi: 10.1007/BF02049917. [DOI] [PubMed] [Google Scholar]
  13. ROWLEY D. A., PINE L. Some nutritional factors influencing growth of yeast cells of Histoplasma capsulatum to mycelial colonies. J Bacteriol. 1955 Jun;69(6):695–700. doi: 10.1128/jb.69.6.695-700.1955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. SCHERR G. H. Studies on the dimorphism of Histoplasma capsulatum. I. The roles of -SH groups and incubation temperature. Exp Cell Res. 1957 Feb;12(1):92–107. doi: 10.1016/0014-4827(57)90296-3. [DOI] [PubMed] [Google Scholar]
  15. Skyring G. W., Trudinger P. A. A method for the electrophoretic characterization of sulfite reductases in crude preparations from sulfate-reducing bacteria using polyacrylamide gels. Can J Biochem. 1972 Oct;50(10):1145–1148. doi: 10.1139/o72-156. [DOI] [PubMed] [Google Scholar]
  16. Stetler D. A., Boguslawski G. Cysteine biosynthesis in a fungus, Histoplasma capsulatum. Sabouraudia. 1979 Mar;17(1):23–34. doi: 10.1080/00362177985380041. [DOI] [PubMed] [Google Scholar]
  17. Tang S. L., Howard D. H., Gupta R. K. Uptake of metabolites by germinating blastospores of Histoplasma capsulatum. Sabouraudia. 1978 Dec;16(4):271–278. doi: 10.1080/00362177885380371. [DOI] [PubMed] [Google Scholar]
  18. Woodward V. W., De Zeeuw J. R., Srb A. M. THE SEPARATION AND ISOLATION OF PARTICULAR BIOCHEMICAL MUTANTS OF NEUROSPORA BY DIFFERENTIAL GERMINATION OF CONIDIA, FOLLOWED BY FILTRATION AND SELECTIVE PLATING. Proc Natl Acad Sci U S A. 1954 Mar;40(3):192–200. doi: 10.1073/pnas.40.3.192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Yen C. M., Howard D. H. Germination of blastospores of Histoplasma capslatum. Sabouraudia. 1970 Nov;8(3):242–252. [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES