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. Author manuscript; available in PMC: 2010 Sep 9.
Published in final edited form as: Cell. 2010 Apr 30;141(3):402–404. doi: 10.1016/j.cell.2010.04.015

Figure 1. Structure of CED-4 and Apaf-1 Apoptosomes.

Figure 1

(A) Conserved domains between Caenorhabditis elegans CED-4 (571 amino acids) and human Apaf-1 (1237 amino acids).

(B) The C. elegans CED-4 octamer apoptosome as viewed from the top (upper) and side (lower).

(C) Human Apaf-1 heptamer apoptosome as viewed from the top (upper) and side (lower).