Table 2. Knowledge of clinical trial concepts and willingness to enroll in an HCV vaccine trial among young, HCV antibody negative IDUs by age in San Francisco, 2006-2007 (n=67).
| Total N (%) |
Age <23 N (%) |
Age ≥23 N (%) |
|
|---|---|---|---|
| Overall | 67 (100) | 25 (37.3) | 42 (62.7) |
| Ever received a vaccine from UFO (n=66) | 19 (28.8) | 1 (4.2) | 18 (42.9)** |
| Vaccine knowledge | |||
| What do you think a vaccine is for? | |||
| To prevent | 47 (70.2) | 21 (84.0) | 26 (61.9) |
| To treat disease | 3 (4.5) | 1 (4.0) | 2 (4.8) |
| To prevent and treat disease | 16 (23.9) | 3(12.0) | 13 (31.0) |
| The study would only enroll people not infected with hcv. [True] | 33 (57.4) | 7 (28.0) | 26 (61.9)* |
| Participants would be randomly assigned to get actual vaccine or placebo. [True] | 30 (44.8) | 13 (52.0) | 17 (40.5) |
| No one knows who received actual vaccine or placebo until trial end [True] | 39 (58.2) | 12 (48.0) | 27 (64.3) |
| Only researchers know who received actual vaccine or placebo before trial end [True] (n=66) | 30 (45.5) | 11 (45.8) | 19 (45.2) |
| Participants told whether received actual vaccine or placebo at trial end [True] | 45 (67.2) | 18 (72.0) | 27 (64.3) |
| Participants would be treated for vaccine related health problems [True] | 53 (79.0) | 19 (76.0) | 34 (81.0) |
| Willingness to enroll | |||
| Willingness to enroll by study length (n=66) | |||
| 1 year | 44 (66.7) | 10 (40.0) | 34 (82.9)** |
| 2 years | 36 (54.6) | 7 (28.0) | 29 (70.7)** |
| 3 years | 30 (45.5) | 7 (28.0) | 23 (56.1)* |
| 4 years | 28 (42.4) | 7 (28.0) | 21 (51.2) |
| Willingness to enroll if study started this week (n=66) | |||
| Definitely willing | 29 (43.9) | 7 (28.0) | 22 (53.7) |
| Probably willing | 29 (43.9) | 13 (52.0) | 16 (39.0) |
| Probably unwilling | 5 (7.6) | 3 (12.0) | 2 (4.9) |
| Definitely unwilling | 3 (4.6) | 2 (8.0) | 1 (2.4) |
| Trust to explain safety and side effects (n=66) | |||
| UFO Study | 58 (87.9) | 20 (80.0) | 38 (92.7) |
| San Francisco DPH | 37 (56.1) | 15 (60.0) | 22 (53.7) |
| UCSF Committee on Human Research | 35 (53.1) | 10 (40.0) | 25 (61.0) |
| San Francisco General Hospital† | 31 (50.8) | 15 (62.5) | 16 (43.2) |
| Doctor | 39 (59.1) | 17 (68.0) | 22 (53.7) |
| Government | 17 (25.8) | 6 (24.0) | 11 (26.8) |
| Pharmaceutical company | 9 (13.6) | 5 (20.0) | 4 (9.8) |
| Media/Newspapers | 6 (9.1) | 2 (8.0) | 4 (9.8) |
*
p<=0.05;
**
p<=0.01;
†
n=61