Abstract
Four caffeine-resistant haploid isolates, two resistant to 50 mM caffeine and two resistant to 100 mM caffeine, were genetically analyzed. Complementation and tetrad analysis indicated that all four mutations are alleles of the same locus. All four isolates demonstrated incomplete dominance when hybridized to the wild-type strain and dominance of high to low resistance when hybridized to one another. Differences in caffeine resistance were found between wild-type grande cells and its petite derivative.
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- Armitt S., Woods R. A. Purine-excreting mutants of Saccharomyces cerevisiae. I. Isolation and genetic analysis. Genet Res. 1970 Feb;15(1):7–17. doi: 10.1017/s0016672300001324. [DOI] [PubMed] [Google Scholar]
- Bard M. Biochemical and genetic aspects of nystatin resistance in saccharomyces cerevisiae. J Bacteriol. 1972 Sep;111(3):649–657. doi: 10.1128/jb.111.3.649-657.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gentner N. E., Werner M. M., Hannan M. A., Nasim A. Contribution of a caffeine-sensitive recombinational repair pathway to survival and mutagenesis in UV-irradiated Schizosaccharomyces pombe. Mol Gen Genet. 1978 Nov 16;167(1):43–49. doi: 10.1007/BF00270320. [DOI] [PubMed] [Google Scholar]
- Hannan M. A., Nasim A. Caffeine enhancement of radiation killing in different strains of Saccharomyces cerevisiae. Mol Gen Genet. 1977 Dec 14;158(1):111–116. doi: 10.1007/BF00455125. [DOI] [PubMed] [Google Scholar]
- Kihlman B. A. Effects of caffeine on the genetic material. Mutat Res. 1974 Apr;26(2):53–71. doi: 10.1016/s0027-5107(74)80036-9. [DOI] [PubMed] [Google Scholar]
- Kihlman B. A., Sturelid S., Hartley-Asp B., Nilsson K. The enhancement by caffeine of the frequencies of chromosomal aberrations induced in plant and animal cells by chemical and physical agents. Mutat Res. 1974 Apr;26(2):105–122. doi: 10.1016/s0027-5107(74)80041-2. [DOI] [PubMed] [Google Scholar]
- Lehmann A. R., Kirk-Bell S. Effects of caffeine and theophylline on DNA synthesis in unirradiated and UV-irradiated mammalian cells. Mutat Res. 1974 Apr;26(2):73–82. doi: 10.1016/s0027-5107(74)80037-0. [DOI] [PubMed] [Google Scholar]
- Lomax C. A., Woods R. A. A complex genetic locus controlling purine nucleotide biosynthesis in yeast. Mol Gen Genet. 1973 Jan 24;120(2):139–149. doi: 10.1007/BF00267242. [DOI] [PubMed] [Google Scholar]
- Loprieno N., Barale R., Baroncelli S. Genetic effects of caffeine. Mutat Res. 1974 Apr;26(2):83–87. doi: 10.1016/s0027-5107(74)80038-2. [DOI] [PubMed] [Google Scholar]
- Pickering W. R., Woods R. A. Genetics of resistance to 4-aminopyrazolo-(3,4-d)-pyrimidine in Saccharomyces cerevisiae. Mol Gen Genet. 1973 May 9;122(3):231–242. doi: 10.1007/BF00278599. [DOI] [PubMed] [Google Scholar]
- Pickering W. R., Woods R. A. The uptake and incorporation of purines by wild-type Saccharomyces cerevisiae and a mutant resistant to 4-aminopyrazolo (3,4-d) pyrimidine. Biochim Biophys Acta. 1972 Mar 30;264(1):45–58. doi: 10.1016/0304-4165(72)90115-8. [DOI] [PubMed] [Google Scholar]
- Slonimski P. P., Perrodin G., Croft J. H. Ethidium bromide induced mutation of yeast mitochondria: complete transformation of cells into respiratory deficient non-chromosomal "petites". Biochem Biophys Res Commun. 1968 Feb 15;30(3):232–239. doi: 10.1016/0006-291x(68)90440-3. [DOI] [PubMed] [Google Scholar]