Figure 3.

Representative histological sections and calcein/demeclocycline labeling of bone femoral sections from 1-month-old Ctgf^+/LacZ heterozygous mice (A), 1-month-old Prx1-Cre/+;Ctgf^INV/INV conditional null mice and littermate Ctgf^{e2COIN/e2COIN} controls (B), and 6-month-old Oc-Cre/+;Ctgf^INV/LacZ conditional null mice and Oc-Cre/+;Ctgf^INV/+ littermate controls (C). Sections from male mice were stained with von Kossa without counterstain (final magnification, ×40) or unstained and examined under fluorescence microscopy (final magnification, ×400). WT, Wild type.