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. 1980 Jul;143(1):492–498. doi: 10.1128/jb.143.1.492-498.1980

Involvement of ribosomal ribonucleic acid operons in Salmonella typhimurium chromosomal rearrangements.

A F Lehner, C W Hill
PMCID: PMC294275  PMID: 6156935

Abstract

As part of our efforts to understand factors influencing chromosomal organization and rearrangements, we studied a family of Salmonella typhimurium tandum duplication mutants. We found that the duplications were originally generated by unequal recombination between pairs of similarly oriented ribosomal ribonucleic acid operons (rrn). This demonstration involved the physical isolation of the duplicated material as circular deoxyribonucleic acid excised from the duplication. The four rrn operons involved embraced the ilv pur D segment of the chromosome and occurred at positions closely analogous to those previously observed for Escherichia coli. The interval between rrnC and rrnA of S. typhimurium was similar in size to that of E. coli (43 versus 39 kilobases), as was the interval between rrnB and rrnE (94 versus 91 kilobases). The rrnA-to-rrnB interval of S. typhimurium, however, was 155 kilobases, substantially greater than the 126 kilobases observed for E. coli.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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