Table 5.
Hydroxylated fatty acid | Healthy subjects | Type-2 diabetic patients |
---|---|---|
9-HODE (pmol/mg cholesterol) | 148 ± 17 | 235 ± 21* |
13-HODE (pmol/mg cholesterol) | 133 ± 18 | 205 ± 17* |
8-HETE (pmol/mg cholesterol) | 26 ± 8 | 44 ± 8 |
11-HETE (pmol/mg cholesterol) | 23 ± 9 | 43 ± 11 |
12-HETE (pmol/mg cholesterol) | 13 ± 6 | 34 ± 7* |
15-HETE (pmol/mg cholesterol) | 29 ± 5 | 54 ± 8* |
HODEs/18:2n-6 (μmol/mol) | 394 ± 39 | 624 ± 42** |
HETEs/20:4n-6 (μmol/mol) | 822 ± 188 | 1222 ± 185 |
Values are means ± S.E.M. of seven subjects per group.
p ≤ 0.05 and
p ≤ 0.01 compared with LDL from healthy subjects.
HETE. hydroxy-eicosatetraenoic acid; HODE. hydroxy-octadecadienoic acid.