Table 4.
Differentially expressed cell cycle, proliferation, and apoptosis genes in preovulatory granulosa cells
| Gene | Description | Fold change (Inha−/−/WT) |
|---|---|---|
| Up in Inha−/− | ||
| Fgfr4 | Fibroblast growth factor receptor 4 | +35.5 |
| Egfr | Epidermal growth factor receptor | +3.8 (+3.4a) |
| Fgfr1 | Fibroblast growth factor receptor 1 | +2.5 |
| Ccne1 | Cyclin E1 | +2.3 (+1.9a) |
| E2f1 | E2F transcription factor 1 | +2.2 (+1.9a) |
| Espl1 | Extra spindle poles-like 1 (Saccharomyces cerevisiae) | +2.1 |
| Down in Inha−/− | ||
| Sfrp4 | Secreted frizzled-related protein 4 | −23.2 (−6.4a) |
| Pik3r1 | Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85α) | −21.0 |
| Pik3ip1 | Phosphoinositide-3-kinase interacting protein 1 | −12.2 |
| Sgk | Serum/glucocorticoid regulated kinase 1 | −4.1 |
| Trp53inp1 | Transformation related protein 53 inducible nuclear protein 1 | −3.9 |
| Myc | Myelocytomatosis oncogene | −3.7 |
| Cflar | CASP8 and Fas-associated death domain-like apoptosis regulator | −2.7 |
| Dhx32 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | −2.6 |
| Pik3cd | Phosphatidylinositol 3-kinase catalytic δ-polypeptide | −2.6 |
Genes in bold were independently validated by qPCR with fold change in parentheses.
a
qPCR statistical significance at P < 0.05.