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. 1980 Dec;144(3):884–890. doi: 10.1128/jb.144.3.884-890.1980

Overproduction of outer membrane protein suppresses envA-induced hyperpermeability.

T Grundström, S Normark, K E Magnusson
PMCID: PMC294749  PMID: 7002913

Abstract

A quantitative study on outer membrane components was performed in a number of envelope mutants of Escherichia coli K-12 exhibition different permeability properties for antimicrobial agents. The envA1 allele causing an increased influx for both hydrophobic and hydrophilic drugs was found to be associated with a deficiency in the amount of lipopolysaccharides. The sefA1 envA1 double mutant was found to have a higher outer membrane buoyant density, apparently due to an increase in protein content. This double mutant was still low in lipopolysaccharide content.

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Selected References

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