Table 2.
Drug resistance mutations by tissue source
| Patient #7 | PBL | Esophagus | Stomach | Duodenum | Colon |
|---|---|---|---|---|---|
| Visit 1 | |||||
| None (100%) | None (20%) | None (25% | ND | ND | |
| ddI | T215Y (20%) | L74V (8.3%) | |||
| M41L, T215Y (40%) | T215Y (16.7%) | ||||
| M41L, T69N, T215Y (20%) | L74V, T215Y (50%) | ||||
| Visit 2 | |||||
| M41L, L74V, T215Y (100%) | T215Y (100%) | None (45.5%) | M41L, T215Y(54.5%) | M41L(33.3%) | |
| ddI | M41L, L74V, T215Y (9.1%) | T215Y (27.3%) | L210W, T215Y(22.2%) | ||
| T215Y (36.4%) | M41L, L74V, T215Y (18.2%) | None (44.4%) | |||
| L74V, T215Y (9.1%) | |||||
| Visit 3 | |||||
| None (87.5%) | M41L (42.9%) | T215Y(93.8%) | M41L (18.2%) | M41L, L210W, T215Y(71.4%) | |
| AZT | F77S (12.5%) | T215Y (57.1%) | L210F, T215Y(6.25%) | None (81.8%) | M41L (14.3%) |
| M41L, V75G (14.3%) | |||||
| Visit 2007 | |||||
| None (100%) | |||||
| HAART | |||||
| Patient #60 | PBL | Esophagus | Stomach | Duodenum | Colon |
| Visit 1 | |||||
| D67N, K70R, T215Y, K219Q (80%) | None (90%) | None (8.3%) | D67N, T69N, K70R, K219Q (100%) | D67N, K70R, K219Q (30%) | |
| AZT | D67N, K70R, K219Q (20%) | E44K (10%) | M41L (8.3%) | D67N, T69N, K70R, K219Q (50%) | |
| K70R, T215Y(83.3%) | D67N, T69N, K70R, F116V, K219Q (10%) | ||||
| E44V, D67N, T69N, K70R, K219Q (10%) | |||||
| Visit 2 | |||||
| None 100% | D67N, T69N, K70R, K219Q (90%) | K70R, T215F (10%) | D67N, K70R, K219Q (50%) | D67N, K70R, T215Y, K219Q (40%) | |
| AZT | K70R, T215Y (10%) | D67N, T69N, K70R, K219Q (10%) | D67N, T69N, K70R, K219Q (50%) | D67N, T69D, K70R, T215Y, K219Q (60%) | |
| K70R, T215Y (80%) | |||||
| Visit 3 | |||||
| None (90.9%) | D67N, T69N, K70R, K219Q (10%) | ND | None (45.5%) | M184T (15.4%) | |
| ddI | M41T (9.1%) | D67G, K70R, T215Y (10%) | K70R, T215Y(18.2%) | D67N, T69D, K70R, T215F, K219Q (76.9%) | |
| D67N, K70R, K219Q (10%) | K70R, T215Y, K219Q (9.1%) | D67N, T69D, K70R, V75I, T215F, K219Q (7.7%) | |||
| K70R, T215Y (70%) | D67N, K70R, T215Y, K219Q (9.1%) | ||||
| D67N, T69D, K70R, T215Y, K219Q (9.1%) | |||||
| D67N, T69N, K70R, T215Y, K219Q (9.1%) | |||||
| Patient #19 | PBL | Esophagus | Stomach | Duodenum | Colon |
| Visit 1 | |||||
| M41I, E44K, D67N, L74V (100%) | K70R (10%) | M41I, E44K, D67N, L74V (40%) | ND | ND | |
| AZT | E44G (10%) | None (60%) | |||
| F77S (10%) | None (60%) | ||||
| D67N, K70R, V118I, T215Y, K219Q (10%) | |||||
| Visit 2 | |||||
| M41L, T215Y (100%) | None (77.8%) | T215Y (100%) | None (50%) | F116K (14.3%) | |
| AZT | D67G (11.1%) | L74V (50%) | None (85.7%) | ||
| T215A (11.1%) | |||||
| Visit 3 | |||||
| T215Y(20%) | M41L, T215Y (100%) | None (25%) | None (77.8%) | M41L, L74V, T215Y (66.7%) | |
| AZT | M41L, T215Y (80%) | K70R (50%) | T215Y (11.1%) | None (33.3%) | |
| L210W, T215Y (16.7%) | M41L, D67G (11.1%) | ||||
| M41L, L210W, T215Y (8.3%) | |||||
| Visit 2007 | |||||
| None (81.8%) | |||||
| HAART | M41L, E44D, T215C (18.2%) | ||||
| Patient #42 | PBL | Esophagus | Stomach | Duodenum | Colon |
| Visit 1 | |||||
| D67N, K70R, V118I, T215Y, K219Q (70%) | K70R, T215Y(100%) | None (58.3%) | M184T (9.1%) | D67N, K70R, V118I, T215F, K219Q (100%) | |
| none | D67N, K70R, V118I, L210F, T215F, K219Q (10%) | D67N, K70R, V118I, T215Y, K219Q (41.7%) | D67N, T69D, K70R, T215F, K219Q (45.5.%) | ||
| D67N, K70R, F116Y, V118I, T215F, K219Q (10%) | None (45.5%) | ||||
| E44D, D67N, K70R, V118I, T215F, K219Q (10%) | |||||
*ND - no viral sequences detected. Primary drug resistance mutations associated with high levels of drug resistance indicated in italics