Table 3.

Results from multivariate models. Each row represents a separate multivariable model.^†

Models	Baseline hormone		Change in hormone from baseline
	Risk Ratio (95% CI)	P Value	Risk Ratio (95% CI)	P Value
Model 1: E2	0.85 (0.69 - 1.05)	0.13	0.90 (0.73 - 1.11)	0.32
Model 2: T	2.04 (1.45 - 2.86)	<0.001	1.28 (0.81 - 2.02)	0.29
Model 3: SHBG	0.58 (0.48 - 0.70)	<0.001	0.80 (0.58 - 1.10)	0.20
Model4: FAI	1.77 (1.50 - 2.09)	<0.001	1.22 (0.93 - 1.60)	0.16
Model 5: RAE	1.41 (1.17 - 1.69) ‡	0.001	1.24 (1.01 - 1.52)	0.04

^†All models were adjusted for ethnicity, age at baseline, residual BMI, ‘phlebotomy in window’, site, physical activity, level of education.

^‡Relative Androgen Excess baseline value is the T/E2 molar ratio at study entry.