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Indian Journal of Psychiatry logoLink to Indian Journal of Psychiatry
. 2004 Jul-Sep;46(3):261–266.

A Comparative Study of Sexual Dysfunction due to Typical and Atypical Antipsychotics in Remitted Bipolar-I Disorder

Anil Kumar M Nagaraj 1, Haque S Nizamie 2,*, Sayeed Akhtar 3, Baxi Neeraj P Sinha 4, Nishant Goyal 5
PMCID: PMC2951652  PMID: 21224908

Abstract

In the remitted phase of bipolar I disorder, sexual dysfunction is commonly due to drugs used in the treatment rather than the disease itself. There are very few studies, especially in the Indian population, addressing the frequency of sexual dysfunction due to antipsychotics in bipolar I disorder. Hence this study was done to determine the sexual dysfunction due to antipsychotics and to compare the same among typical and atypical antipsychotics. A cross sectional study with 108 male patients of remitted bipolar I disorder (DSM-IV), chosen by purposive sampling technique was done. Psychopathology was assessed using the Brief Psychiatric Rating Scale, Structured Interview Guide for the Hamilton Depression Rating Scale and Young Mania Rating Scale. Sexual side effects due to antipsychotics were assessed using the Udvalg for Kliniske ndersogelser (UKU) side effect rating scale. The total sample size was divided into two groups of those on typical antipsychotics (n = 53) and atypical antipsychotics (n = 55). The two groups were compared for sexual dysfunction using Chi-square test. Results showed dysfunction in at least one phase of the sexual response cycle, comprising of desire, arousal and orgasm, was present in 66% of the sample population. Erectile dysfunction was present in 42% of the sample population and it was the most common type of sexual dysfunction reported. It was also significantly different across the two groups (p = 0.025). There was no significant difference in other aspects of sexual dysfunction across the two groups. In conclusion patients of Bipolar I disorder experience sexual side effects of antipsychotics frequently. Erectile dysfunction is the most common sexual dysfunction among men and this is significantly higher with typical than atypical antipsychotics.

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Selected References

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  1. Aizenberg D., Modai I., Landa A., Gil-Ad I., Weizman A. Comparison of sexual dysfunction in male schizophrenic patients maintained on treatment with classical antipsychotics versus clozapine. J Clin Psychiatry. 2001 Jul;62(7):541–544. doi: 10.4088/jcp.v62n07a07. [DOI] [PubMed] [Google Scholar]
  2. Aizenberg D., Sigler M., Zemishlany Z., Weizman A. Lithium and male sexual function in affective patients. Clin Neuropharmacol. 1996 Dec;19(6):515–519. doi: 10.1097/00002826-199619060-00005. [DOI] [PubMed] [Google Scholar]
  3. Aizenberg D., Zemishlany Z., Dorfman-Etrog P., Weizman A. Sexual dysfunction in male schizophrenic patients. J Clin Psychiatry. 1995 Apr;56(4):137–141. [PubMed] [Google Scholar]
  4. Bobes J., Garc A-Portilla M. P., Rejas J., Hern Ndez G., Garcia-Garcia M., Rico-Villademoros F., Porras A. Frequency of sexual dysfunction and other reproductive side-effects in patients with schizophrenia treated with risperidone, olanzapine, quetiapine, or haloperidol: the results of the EIRE study. J Sex Marital Ther. 2003 Mar-Apr;29(2):125–147. doi: 10.1080/713847170. [DOI] [PubMed] [Google Scholar]
  5. Burke M. A., McEvoy J. P., Ritchie J. C. A pilot study of a structured interview addressing sexual function in men with schizophrenia. Biol Psychiatry. 1994 Jan 1;35(1):32–35. doi: 10.1016/0006-3223(94)91164-9. [DOI] [PubMed] [Google Scholar]
  6. Ghadirian A. M., Annable L., Bélanger M. C. Lithium, benzodiazepines, and sexual function in bipolar patients. Am J Psychiatry. 1992 Jun;149(6):801–805. doi: 10.1176/ajp.149.6.801. [DOI] [PubMed] [Google Scholar]
  7. Gitlin M. J. Psychotropic medications and their effects on sexual function: diagnosis, biology, and treatment approaches. J Clin Psychiatry. 1994 Sep;55(9):406–413. [PubMed] [Google Scholar]
  8. Hummer M., Kemmler G., Kurz M., Kurzthaler I., Oberbauer H., Fleischhacker W. W. Sexual disturbances during clozapine and haloperidol treatment for schizophrenia. Am J Psychiatry. 1999 Apr;156(4):631–633. doi: 10.1176/ajp.156.4.631. [DOI] [PubMed] [Google Scholar]
  9. Kockott G., Pfeiffer W. Sexual disorders in nonacute psychiatric outpatients. Compr Psychiatry. 1996 Jan-Feb;37(1):56–61. doi: 10.1016/s0010-440x(96)90052-8. [DOI] [PubMed] [Google Scholar]
  10. Kotin J., Wilbert D. E., Verburg D., Soldinger S. M. Thioridazine and sexual dysfunction. Am J Psychiatry. 1976 Jan;133(1):82–85. doi: 10.1176/ajp.133.1.82. [DOI] [PubMed] [Google Scholar]
  11. Kristensen E., Jørgensen P. Sexual function in lithium-treated manic-depressive patients. Pharmacopsychiatry. 1987 Jul;20(4):165–167. doi: 10.1055/s-2007-1017096. [DOI] [PubMed] [Google Scholar]
  12. Lingjaerde O., Ahlfors U. G., Bech P., Dencker S. J., Elgen K. The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand Suppl. 1987;334:1–100. doi: 10.1111/j.1600-0447.1987.tb10566.x. [DOI] [PubMed] [Google Scholar]
  13. Macdonald S., Halliday J., MacEWAN T., Sharkey V., Farrington S., Wall S., McCreadie R. G. Nithsdale Schizophrenia Surveys 24: sexual dysfunction. Case-control study. Br J Psychiatry. 2003 Jan;182:50–56. doi: 10.1192/bjp.182.1.50. [DOI] [PubMed] [Google Scholar]
  14. Meston C. M., Frohlich P. F. The neurobiology of sexual function. Arch Gen Psychiatry. 2000 Nov;57(11):1012–1030. doi: 10.1001/archpsyc.57.11.1012. [DOI] [PubMed] [Google Scholar]
  15. Raja Michele, Azzoni Antonella. Sexual behavior and sexual problems among patients with severe chronic psychoses. Eur Psychiatry. 2003 Mar;18(2):70–76. doi: 10.1016/s0924-9338(03)00009-9. [DOI] [PubMed] [Google Scholar]
  16. Smith S. M., O'Keane V., Murray R. Sexual dysfunction in patients taking conventional antipsychotic medication. Br J Psychiatry. 2002 Jul;181:49–55. doi: 10.1192/bjp.181.1.49. [DOI] [PubMed] [Google Scholar]
  17. Williams J. B. A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry. 1988 Aug;45(8):742–747. doi: 10.1001/archpsyc.1988.01800320058007. [DOI] [PubMed] [Google Scholar]
  18. Wirshing Donna A., Pierre Joseph M., Marder Stephen R., Saunders C. Scott, Wirshing William C. Sexual side effects of novel antipsychotic medications. Schizophr Res. 2002 Jul 1;56(1-2):25–30. doi: 10.1016/s0920-9964(01)00271-7. [DOI] [PubMed] [Google Scholar]
  19. Young R. C., Biggs J. T., Ziegler V. E., Meyer D. A. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 1978 Nov;133:429–435. doi: 10.1192/bjp.133.5.429. [DOI] [PubMed] [Google Scholar]

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