Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Oct 5;1(4):e00176-10. doi: 10.1128/mBio.00176-10

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2010 De Miranda et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

FIG 1 — Poly(I ⋅ C) treatment during gestation impairs early locomotor development in neonates and prepulse inhibition (PPI) in adult mice. (a) WT C57BL/6 pregnant mice were treated with either PBS or poly(I ⋅ C) (5 mg/kg) on gestational day 16 (GD16). Protoambulatory behavior of the offspring from pregnant mice treated with PBS or poly(I ⋅ C) was measured in an open-field paradigm. Data are presented as the number of floor plane (FP) moves exhibited by the mice on postnatal day 8. The values for the poly(I ⋅ C)-treated group are significantly different (P < 0.05 by the Mann-Whitney U test) compared to the values for the PBS-treated control group as indicated by the bracket and asterisk. The height of the box plot shows the interquartile range, and the horizontal line indicates the median. The range is indicated by the error bars, and the circles represent outlier values. (b) Sensorimotor gating of the acoustic startle reflex was measured as a percentage of prepulse inhibition in the adult offspring from WT C57BL/6 dams injected on GD16 with either PBS (white bars) or poly(I ⋅ C) (5 mg/kg) (hatched bars). Data are presented as the percent PPI exhibited at each of the four prepulse intensity trials (2, 4, 8, and 16 dB above background noise) by the mice during postnatal weeks 15 to 17. The values for the poly(I ⋅ C)-treated group are significantly different (P < 0.05 by Fisher’s protected least-significant difference [PLSD] test) compared to the values for the PBS-treated control group as indicated by the bracket and asterisk.