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Indian Journal of Psychiatry logoLink to Indian Journal of Psychiatry
. 2002 Apr-Jun;44(2):97–107.

EEG ALPHA COHERENCE AND PSYCHOPATHOLOGICAL DIMENSIONS OF SCHIZOPHRENIA

John P John *,*, Sumant Khanna †, N Pradhan ‡, CR Mukundan §
PMCID: PMC2954356  PMID: 21206554

Abstract

The aim of this study was to evaluate the correlation between psychopathological dimensions in recent-onset neuroleptic-naive schizophrenic patients and EEG alpha coherence in the resting state. 37 neuroleptic-naive recent-onset schizophrenic patients were assessed on the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms, and psychopathological dimension scores on reality distortion, psychomotor poverty and disorganization were calculated. EEG alpha coherence was computed across 14 intra-hemispheric and 8 interhemispheric electrode pairs in the resting eyes closed and eyes open conditions. The relationship between the psychopathological dimension scores and coherence values was assessed using Pearson's product moment correlation with Bonferroni correction for levels of significance. Significant associations between higher psychomotor poverty scores and lower inter-hemispheric coherence values were found across the central and parietal regions in the eyes closed condition and across central regions in the eyes open condition. Reality distortion and disorganization dimensions were not significantly correlated with intra- or inter-hemispheric coherences in both eyes closed and eyes open conditions. However there was a trend for an inverse correlation between disorganization dimension and intra-hemispheric coherence across left frontal, left temporo-parietal and right parieto-occipital regions in the eyes open condition. These findings suggest a possible differential pattern in the extent of brain involvement across the three psychopathological dimensions of schizophrenia in neurolepticnaive patients with recent-onset illness.

Keywords: schizophrenia, dimensions, drug-naive, EEG, alpha coherence, disconnection

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Selected References

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  1. Amador X. F., Gorman J. M. Psychopathologic domains and insight in schizophrenia. Psychiatr Clin North Am. 1998 Mar;21(1):27–42. doi: 10.1016/s0193-953x(05)70359-2. [DOI] [PubMed] [Google Scholar]
  2. Andreasen N. C., Arndt S., Alliger R., Miller D., Flaum M. Symptoms of schizophrenia. Methods, meanings, and mechanisms. Arch Gen Psychiatry. 1995 May;52(5):341–351. doi: 10.1001/archpsyc.1995.03950170015003. [DOI] [PubMed] [Google Scholar]
  3. Andreasen N. C., Olsen S. Negative v positive schizophrenia. Definition and validation. Arch Gen Psychiatry. 1982 Jul;39(7):789–794. doi: 10.1001/archpsyc.1982.04290070025006. [DOI] [PubMed] [Google Scholar]
  4. Annett M. A coordination of hand preference and skill replicated. Br J Psychol. 1976 Nov;67(4):587–592. doi: 10.1111/j.2044-8295.1976.tb01550.x. [DOI] [PubMed] [Google Scholar]
  5. Arndt S., Alliger R. J., Andreasen N. C. The distinction of positive and negative symptoms. The failure of a two-dimensional model. Br J Psychiatry. 1991 Mar;158:317–322. doi: 10.1192/bjp.158.3.317. [DOI] [PubMed] [Google Scholar]
  6. Baxter R. D., Liddle P. F. Neuropsychological deficits associated with schizophrenic syndromes. Schizophr Res. 1998 Apr 10;30(3):239–249. doi: 10.1016/s0920-9964(97)00152-7. [DOI] [PubMed] [Google Scholar]
  7. Gureje O., Aderibigbe Y. A., Obikoya O. Three syndromes in schizophrenia: validity in young patients with recent onset of illness. Psychol Med. 1995 Jul;25(4):715–725. doi: 10.1017/s0033291700034966. [DOI] [PubMed] [Google Scholar]
  8. Harrow M., Silverstein M., Marengo J. Disordered thinking. Arch Gen Psychiatry. 1983 Jul;40(7):765–771. doi: 10.1001/archpsyc.1983.01790060063008. [DOI] [PubMed] [Google Scholar]
  9. Kaplan R. D., Szechtman H., Franco S., Szechtman B., Nahmias C., Garnett E. S., List S., Cleghorn J. M. Three clinical syndromes of schizophrenia in untreated subjects: relation to brain glucose activity measured by positron emission tomography (PET). Schizophr Res. 1993 Dec;11(1):47–54. doi: 10.1016/0920-9964(93)90037-j. [DOI] [PubMed] [Google Scholar]
  10. Kay S. R., Sevy S. Pyramidical model of schizophrenia. Schizophr Bull. 1990;16(3):537–545. doi: 10.1093/schbul/16.3.537. [DOI] [PubMed] [Google Scholar]
  11. Kulhara P., Kota S. K., Joseph S. Positive and negative subtypes of schizophrenia. A study from India. Acta Psychiatr Scand. 1986 Oct;74(4):353–359. doi: 10.1111/j.1600-0447.1986.tb06254.x. [DOI] [PubMed] [Google Scholar]
  12. Liddle P. F., Friston K. J., Frith C. D., Hirsch S. R., Jones T., Frackowiak R. S. Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry. 1992 Feb;160:179–186. doi: 10.1192/bjp.160.2.179. [DOI] [PubMed] [Google Scholar]
  13. Liddle P. F. Functional imaging--schizophrenia. Br Med Bull. 1996 Jul;52(3):486–494. doi: 10.1093/oxfordjournals.bmb.a011562. [DOI] [PubMed] [Google Scholar]
  14. Liddle P. F., Morris D. L. Schizophrenic syndromes and frontal lobe performance. Br J Psychiatry. 1991 Mar;158:340–345. doi: 10.1192/bjp.158.3.340. [DOI] [PubMed] [Google Scholar]
  15. Liddle P. F. Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychol Med. 1987 Feb;17(1):49–57. doi: 10.1017/s0033291700012976. [DOI] [PubMed] [Google Scholar]
  16. Liddle P. F. The symptoms of chronic schizophrenia. A re-examination of the positive-negative dichotomy. Br J Psychiatry. 1987 Aug;151:145–151. doi: 10.1192/bjp.151.2.145. [DOI] [PubMed] [Google Scholar]
  17. Merrin E. L., Floyd T. C., Fein G. EEG coherence in unmedicated schizophrenic patients. Biol Psychiatry. 1989 Jan;25(1):60–66. doi: 10.1016/0006-3223(89)90147-9. [DOI] [PubMed] [Google Scholar]
  18. Merrin E. L., Floyd T. C. Negative symptoms and EEG alpha activity in schizophrenic patients. Schizophr Res. 1992 Oct;8(1):11–20. doi: 10.1016/0920-9964(92)90056-b. [DOI] [PubMed] [Google Scholar]
  19. Merrin E. L., Floyd T. C. Negative symptoms and EEG alpha in schizophrenia: a replication. Schizophr Res. 1996 May;19(2-3):151–161. doi: 10.1016/0920-9964(96)88522-7. [DOI] [PubMed] [Google Scholar]
  20. Morrison-Stewart S. L., Velikonja D., Corning W. C., Williamson P. Aberrant interhemispheric alpha coherence on electroencephalography in schizophrenic patients during activation tasks. Psychol Med. 1996 May;26(3):605–612. doi: 10.1017/s0033291700035674. [DOI] [PubMed] [Google Scholar]
  21. Morrison-Stewart S. L., Williamson P. C., Corning W. C., Kutcher S. P., Merskey H. Coherence on electroencephalography and aberrant functional organisation of the brain in schizophrenic patients during activation tasks. Br J Psychiatry. 1991 Nov;159:636–644. doi: 10.1192/bjp.159.5.636. [DOI] [PubMed] [Google Scholar]
  22. Nagase Y., Okubo Y., Matsuura M., Kojima T., Toru M. EEG coherence in unmedicated schizophrenic patients: topographical study of predominantly never medicated cases. Biol Psychiatry. 1992 Dec 1;32(11):1028–1034. doi: 10.1016/0006-3223(92)90064-7. [DOI] [PubMed] [Google Scholar]
  23. Norman R. M., Malla A. K., Williamson P. C., Morrison-Stewart S. L., Helmes E., Cortese L. EEG coherence and syndromes in schizophrenia. Br J Psychiatry. 1997 May;170:411–415. doi: 10.1192/bjp.170.5.411. [DOI] [PubMed] [Google Scholar]
  24. Peralta V., de Leon J., Cuesta M. J. Are there more than two syndromes in schizophrenia? A critique of the positive-negative dichotomy. Br J Psychiatry. 1992 Sep;161:335–343. doi: 10.1192/bjp.161.3.335. [DOI] [PubMed] [Google Scholar]
  25. Rappelsberger P., Petsche H. Probability mapping: power and coherence analyses of cognitive processes. Brain Topogr. 1988 Fall;1(1):46–54. doi: 10.1007/BF01129339. [DOI] [PubMed] [Google Scholar]
  26. Sabri O., Erkwoh R., Schreckenberger M., Owega A., Sass H., Buell U. Correlation of positive symptoms exclusively to hyperperfusion or hypoperfusion of cerebral cortex in never-treated schizophrenics. Lancet. 1997 Jun 14;349(9067):1735–1739. doi: 10.1016/S0140-6736(96)08380-8. [DOI] [PubMed] [Google Scholar]
  27. Shaw J. C., Colter N., Resek G. EEG coherence, lateral preference and schizophrenia. Psychol Med. 1983 May;13(2):299–306. doi: 10.1017/s0033291700050911. [DOI] [PubMed] [Google Scholar]
  28. Tamminga C. A., Thaker G. K., Buchanan R., Kirkpatrick B., Alphs L. D., Chase T. N., Carpenter W. T. Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch Gen Psychiatry. 1992 Jul;49(7):522–530. doi: 10.1001/archpsyc.1992.01820070016003. [DOI] [PubMed] [Google Scholar]
  29. Tauscher J., Fischer P., Neumeister A., Rappelsberger P., Kasper S. Low frontal electroencephalographic coherence in neuroleptic-free schizophrenic patients. Biol Psychiatry. 1998 Sep 15;44(6):438–447. doi: 10.1016/s0006-3223(97)00428-9. [DOI] [PubMed] [Google Scholar]
  30. Thatcher R. W., Krause P. J., Hrybyk M. Cortico-cortical associations and EEG coherence: a two-compartmental model. Electroencephalogr Clin Neurophysiol. 1986 Aug;64(2):123–143. doi: 10.1016/0013-4694(86)90107-0. [DOI] [PubMed] [Google Scholar]
  31. The flight from science. Br Med J. 1980 Jan 5;280(6206):1–2. [PMC free article] [PubMed] [Google Scholar]
  32. Van der Does A. J., Linszen D. H., Dingemans P. M., Nugter M. A., Scholte W. F. A dimensional and categorical approach to the symptomatology of recent-onset schizophrenia. J Nerv Ment Dis. 1993 Dec;181(12):744–749. doi: 10.1097/00005053-199312000-00006. [DOI] [PubMed] [Google Scholar]
  33. Wada Y., Nanbu Y., Jiang Z. Y., Koshino Y., Hashimoto T. Interhemispheric EEG coherence in never-medicated patients with paranoid schizophrenia: analysis at rest and during photic stimulation. Clin Electroencephalogr. 1998 Oct;29(4):170–176. doi: 10.1177/155005949802900408. [DOI] [PubMed] [Google Scholar]
  34. Wada Y., Nanbu Y., Kikuchi M., Koshino Y., Hashimoto T. Aberrant functional organization in schizophrenia: analysis of EEG coherence during rest and photic stimulation in drug-naive patients. Neuropsychobiology. 1998;38(2):63–69. doi: 10.1159/000026518. [DOI] [PubMed] [Google Scholar]
  35. Winterer G., Egan M. F., Rädler T., Hyde T., Coppola R., Weinberger D. R. An association between reduced interhemispheric EEG coherence in the temporal lobe and genetic risk for schizophrenia. Schizophr Res. 2001 Apr 15;49(1-2):129–143. doi: 10.1016/s0920-9964(00)00128-6. [DOI] [PubMed] [Google Scholar]
  36. Wolkin A., Sanfilipo M., Wolf A. P., Angrist B., Brodie J. D., Rotrosen J. Negative symptoms and hypofrontality in chronic schizophrenia. Arch Gen Psychiatry. 1992 Dec;49(12):959–965. doi: 10.1001/archpsyc.1992.01820120047007. [DOI] [PubMed] [Google Scholar]

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