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. 2010 Sep 30;405(2-3):483–491. doi: 10.1016/j.virol.2010.06.002

Fig. 1.

Fig. 1

Measurement of HLA-B*57/5801 and HLA-Cw*07-restricted T cell responses by Interferon-gamma ELISPOT assay. (A) Hierarchy of dominant epitopes presented by the study subjects expressing HLA-B*57/5801 and HLA-Cw*07 alleles (n = 9). Dotted line indicates responses above 500 SFCs from ELISPOT assay that were further tested in subsequent multicolor assays. (B) Combined total magnitude of T cell responses presented by both HLA-B*57/B5801 and HLA-Cw*07 restricted epitopes in the study individuals (n = 9). (C) Percentage of epitope recognition (>100 SFCs/106 ELISPOT responses) of the dominant epitopes presented by different HLA-B57/5801 alleles (B*5701, B*5703 and B*5801) in all chronically infected subjects coexpressing HLA-Cw*07 (n = 37).