TABLE 1.
Group | No. of dogs |
Days after PCS |
TGF-β dose (ng/kg/day) |
No. of labeled hepatocytes per 1,000 hepatocytesa |
Cell size unitsa |
||
---|---|---|---|---|---|---|---|
Left lobe | Right lobe | Left lobe | Right lobe | ||||
1 | 2 | No surgery | – | 1.55 ± 0.18 | 1.55 ± 0.08 | 0.161 ± 0.002 | 0.160 ± 0.003 |
2 | 3 | 1 | – | 1.43 ± 0.43 | 1.36 ± 0.4 | 0.192 ± 0.02 | 0.192 ± 0.023 |
3 | 3 | 2 | – | 6.33 ± 0.82a | 6.26 ± 0.64b | 0.134 ± 0.008b | 0.134 ± 0.009b |
4 | 3 | 3 | – | 5.03 ± 0.27b | 4.96 ± 0.3b | 0.128 ± 0.009b | 0.130 ± 0.008b |
5 | 4 | 4 | – | 4.4 ± 0.3b | 4.2 ± 0.3b | 0.095 ± 0.01b | 0.096 ± 0.015b |
6 | 3 | 4 | 5 | 2.4 ± 0.5c, d | 4.6 ± 0.8 | 0.064 ± 0.02c, d | 0.103 ± 0.01 |
7 | 2 | 4 | 50 | 2.1 ± 0.05c, d | 4.9 ± 0.7 | 0.071 ± 0.006c, d | 0.106 ± 0.004 |
PCS = portacaval shunt.
Group 1: dogs that did not undergo surgery; groups 2 to 5: dogs 1 to 4 days after PCS; groups 6 and 7: dogs with PCS and 4-day continuous infusion of TGF-β into the left branch of the portal vein.
Data expressed as mean ± S.D.
p < 0.001 vs. groups 1 and 2.
p < 0.01 vs. own right lobe.
p < 0.05 vs. left lobe of group 5.