Table 4.

Results of confirmatory association testing for SNPs, ordered by physicial position, which showed the most significant differences in MAF (p≤0.010) between Rejectors and Non-Rejectors (last column). Of 14 such SNPs, five are near HLA-DOA. Among them, rs9296068 and rs9276994 show MAF, which are greater among Rejectors (R), and less among Non-rejectors (NR), compared with 400 normal control Caucasian children (NC). Only rs9296068 shows differences in PAF between outcome groups, satisfying selection criteria for candidacy, while rs9276994 fails the PAF test.

			Allele	Frequency		Chi-square test p-values
SNP	Physical location	Closest Gene	R	NR	NC	R vs NC	NR vs NC	R vs NR
rs2517904	29,976,963	HCG2P7	2.9%	15.9%	7.5%	0.147	0.009	0.007
rs3134879	30,123,884	ZNRD1	26.6%	48.7%	41.1%	0.023	0.192	0.007
rs9366752	30,132,656	ZNRD1	34.3%	15.9%	20.0%	0.005	0.368	0.008
rs9261441	30,199,737	TRIM31	15.7%	3.7%	13.6%	0.623	0.01	0.01
rs1345229	30,290,374	TRIM26	14.3%	2.4%	11.9%	0.553	0.009	0.007
rs1264583	30,401,462	TRIM39	14.3%	2.4%	5.0%	0.001	0.3	0.007
rs1264581	30,405,484	TRIM39	16.2%	3.7%	5.3%	0.000	0.524	0.009
rs3094097	30,741,854	DHX16	14.3%	2.4%	9.8%	0.228	0.028	0.007
rs602875	32,681,607	HLA-DRB1	42.9%	22.0%	23.8%	0.000	0.707	0.006
rs6457699	33,089,625	HLA-DOA	54.3%	31.7%	46.8%	0.226	0.009	0.005
rs9276994	33092233	HLA-DOA	48.6%	28.1%	37.8%	0.075	0.083	0.009
rs6933994	33095098	HLA-DOA	57.1%	36.3%	46.0%	0.614	0.002	0.01
rs9296068	33,096,673	HLA-DOA	51.4%	26.8%	36.8%	0.015	0.074	0.002
rs9277015	33,101,244	HLA-DOA	44.3%	24.4%	37.0%	0.228	0.023	0.01