Abstract
The investigation was conducted to find out whether there is any association between delusional disorder and HLA antigens. The sample comprised 50 patients with delusional disorder and 282 control samples collected from normal controls. Statistical analysis revealed that the frequency of A3 antigen of the locus A are significantly higher. In case of HLA - B locus significantly higher frequency of B5 and B21 antigens have also been observed. The present study shows that there may be some association of HLA class-1 antigens with delusional disorder.
Keywords: Delusion, HLAantigens, microlymphocytotoxicity assay, linkage disequilibrium, psychopathology
Full Text
The Full Text of this article is available as a PDF (182.2 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- McGuffin P., Owen M. The molecular genetics of schizophrenia: an overview and forward view. Eur Arch Psychiatry Clin Neurosci. 1991;240(3):169–173. doi: 10.1007/BF02190759. [DOI] [PubMed] [Google Scholar]
- TERASAKI P. I., MCCLELLAND J. D. MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS. Nature. 1964 Dec 5;204:998–1000. doi: 10.1038/204998b0. [DOI] [PubMed] [Google Scholar]
- Tait B. D., Finlay R. I., Simons M. J. Serum HLA typing. Tissue Antigens. 1981 Feb;17(2):129–135. doi: 10.1111/j.1399-0039.1981.tb00677.x. [DOI] [PubMed] [Google Scholar]