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. 1991 Jul;88(1):101–105. doi: 10.1172/JCI115264

Impaired autoregulation of glomerular capillary hydrostatic pressure in the rat remnant nephron.

J C Pelayo 1, J Y Westcott 1
PMCID: PMC296008  PMID: 2056114

Abstract

In the present micropuncture study, the autoregulation of glomerular capillary hydrostatic pressure (PG) in Munich-Wistar rats 24 h after 75% nephrectomy (Nx) or sham operation (Sh) was investigated. The effect of varying renal perfusion pressure (RPP) on paired determinations of directly measured PG was evaluated in glomeruli of nephrons in which distal fluid delivery was present (unblocked). Autoregulation of PG in Sh glomeruli with unblocked tubules occurred at RPP values between 99.5 +/- 1.0 and 132.1 +/- 1.0 mmHg. In contrast, in Nx glomeruli with unblocked tubules PG increased by 0.32 +/- 0.07 mmHg/mmHg increase in RPP over this same range of RPP (P less than 0.0001). To determine whether enhanced prostaglandins synthesis was responsible for the altered regulation of PG in Nx glomeruli, we repeated the micropuncture measurements in a setting of prostaglandin synthesis inhibition. Although prostaglandins synthesis inhibition did not affect the autoregulation of PG in Sh glomeruli, it did normalize the autoregulatory capacity for PG of Nx glomeruli with unblocked tubules. Thus, acute Nx is associated with a significant loss of the autoregulatory capacity for PG and this impairment appears to be related to a prostaglandin-mediated alteration of the responsiveness of the vascular effector site for autoregulation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arendshorst W. J. Altered reactivity of tubuloglomerular feedback. Annu Rev Physiol. 1987;49:295–317. doi: 10.1146/annurev.ph.49.030187.001455. [DOI] [PubMed] [Google Scholar]
  2. Aukland K., Oien A. H. Renal autoregulation: models combining tubuloglomerular feedback and myogenic response. Am J Physiol. 1987 Apr;252(4 Pt 2):F768–F783. doi: 10.1152/ajprenal.1987.252.4.F768. [DOI] [PubMed] [Google Scholar]
  3. Bell P. D., Franco M., Navar L. G. Calcium as a mediator of tubuloglomerular feedback. Annu Rev Physiol. 1987;49:275–293. doi: 10.1146/annurev.ph.49.030187.001423. [DOI] [PubMed] [Google Scholar]
  4. Bell P. D., Navar L. G. Stop-flow pressure feedback responses during reduced renal vascular resistance in the dog. Am J Physiol. 1979 Sep;237(3):F204–F209. doi: 10.1152/ajprenal.1979.237.3.F204. [DOI] [PubMed] [Google Scholar]
  5. Bidani A. K., Schwartz M. M., Lewis E. J. Renal autoregulation and vulnerability to hypertensive injury in remnant kidney. Am J Physiol. 1987 Jun;252(6 Pt 2):F1003–F1010. doi: 10.1152/ajprenal.1987.252.6.F1003. [DOI] [PubMed] [Google Scholar]
  6. Blantz R. C., Pelayo J. C. A functional role for the tubuloglomerular feedback mechanism. Kidney Int. 1984 May;25(5):739–746. doi: 10.1038/ki.1984.84. [DOI] [PubMed] [Google Scholar]
  7. Brenner B. M. Nephron adaptation to renal injury or ablation. Am J Physiol. 1985 Sep;249(3 Pt 2):F324–F337. doi: 10.1152/ajprenal.1985.249.3.F324. [DOI] [PubMed] [Google Scholar]
  8. Briggs J. P., Schnermann J. The tubuloglomerular feedback mechanism: functional and biochemical aspects. Annu Rev Physiol. 1987;49:251–273. doi: 10.1146/annurev.ph.49.030187.001343. [DOI] [PubMed] [Google Scholar]
  9. Briggs J. P., Wright F. S. Feedback control of glomerular filtration rate: site of the effector mechanism. Am J Physiol. 1979 Jan;236(1):F40–F47. doi: 10.1152/ajprenal.1979.236.1.F40. [DOI] [PubMed] [Google Scholar]
  10. Carmines P. K., Inscho E. W., Gensure R. C. Arterial pressure effects on preglomerular microvasculature of juxtamedullary nephrons. Am J Physiol. 1990 Jan;258(1 Pt 2):F94–102. doi: 10.1152/ajprenal.1990.258.1.F94. [DOI] [PubMed] [Google Scholar]
  11. Hostetter T. H., Olson J. L., Rennke H. G., Venkatachalam M. A., Brenner B. M. Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol. 1981 Jul;241(1):F85–F93. doi: 10.1152/ajprenal.1981.241.1.F85. [DOI] [PubMed] [Google Scholar]
  12. Iversen B. M., Ofstad J. Loss of renal blood flow autoregulation in chronic glomerulonephritic rats. Am J Physiol. 1988 Feb;254(2 Pt 2):F284–F290. doi: 10.1152/ajprenal.1988.254.2.F284. [DOI] [PubMed] [Google Scholar]
  13. Klahr S., Schreiner G., Ichikawa I. The progression of renal disease. N Engl J Med. 1988 Jun 23;318(25):1657–1666. doi: 10.1056/NEJM198806233182505. [DOI] [PubMed] [Google Scholar]
  14. Moore L. C. Tubuloglomerular feedback and SNGFR autoregulation in the rat. Am J Physiol. 1984 Aug;247(2 Pt 2):F267–F276. doi: 10.1152/ajprenal.1984.247.2.F267. [DOI] [PubMed] [Google Scholar]
  15. Müller-Suur R., Norlén B. J., Persson A. E. Resetting of tubuloglomerular feedback in rat kidneys after unilateral nephrectomy. Kidney Int. 1980 Jul;18(1):48–57. doi: 10.1038/ki.1980.109. [DOI] [PubMed] [Google Scholar]
  16. Navar L. G., Chomdej B., Bell P. D. Absence of estimated glomerular pressure autoregulation during interrupted distal delivery. Am J Physiol. 1975 Dec;229(6):1596–1603. doi: 10.1152/ajplegacy.1975.229.6.1596. [DOI] [PubMed] [Google Scholar]
  17. Navar L. G., Ploth D. W., Bell P. D. Distal tubular feedback control of renal hemodynamics and autoregulation. Annu Rev Physiol. 1980;42:557–571. doi: 10.1146/annurev.ph.42.030180.003013. [DOI] [PubMed] [Google Scholar]
  18. Navar L. G. Renal autoregulation: perspectives from whole kidney and single nephron studies. Am J Physiol. 1978 May;234(5):F357–F370. doi: 10.1152/ajprenal.1978.234.5.F357. [DOI] [PubMed] [Google Scholar]
  19. Pelayo J. C., Fildes R. D., Eisner G. M., Jose P. A. Effects of dopamine blockade on renal sodium excretion. Am J Physiol. 1983 Aug;245(2):F247–F253. doi: 10.1152/ajprenal.1983.245.2.F247. [DOI] [PubMed] [Google Scholar]
  20. Pelayo J. C., Quan A. G. Pathophysiology of glomerular hemodynamic adaptations to nephron loss. Semin Nephrol. 1989 Mar;9(1):10–13. [PubMed] [Google Scholar]
  21. Pelayo J. C., Quan A. H., Shanley P. F. Angiotensin II control of the renal microcirculation in rats with reduced renal mass. Am J Physiol. 1990 Feb;258(2 Pt 2):F414–F422. doi: 10.1152/ajprenal.1990.258.2.F414. [DOI] [PubMed] [Google Scholar]
  22. Pelayo J. C., Shanley P. F. Glomerular and tubular adaptive responses to acute nephron loss in the rat. Effect of prostaglandin synthesis inhibition. J Clin Invest. 1990 Jun;85(6):1761–1769. doi: 10.1172/JCI114633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Pelayo J. C., Ziegler M. G., Jose P. A., Blantz R. C. Renal denervation in the rat: analysis of glomerular and proximal tubular function. Am J Physiol. 1983 Jan;244(1):F70–F77. doi: 10.1152/ajprenal.1983.244.1.F70. [DOI] [PubMed] [Google Scholar]
  24. Pradelles P., Grassi J., Maclouf J. Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay. Anal Chem. 1985 Jun;57(7):1170–1173. doi: 10.1021/ac00284a003. [DOI] [PubMed] [Google Scholar]
  25. Robertson C. R., Deen W. M., Troy J. L., Brenner B. M. Dynamics of glomerular ultrafiltration in the rat. 3. Hemodynamics and autoregulation. Am J Physiol. 1972 Nov;223(5):1191–1200. doi: 10.1152/ajplegacy.1972.223.5.1191. [DOI] [PubMed] [Google Scholar]
  26. Schnermann J., Briggs J. P. Interaction between loop of Henle flow and arterial pressure as determinants of glomerular pressure. Am J Physiol. 1989 Mar;256(3 Pt 2):F421–F429. doi: 10.1152/ajprenal.1989.256.3.F421. [DOI] [PubMed] [Google Scholar]
  27. Selén G., Persson A. E. Hydrostatic and oncotic pressures in the interstitium of dehydrated and volume expanded rats. Acta Physiol Scand. 1983 Jan;117(1):75–81. doi: 10.1111/j.1748-1716.1983.tb07180.x. [DOI] [PubMed] [Google Scholar]
  28. Shimamura T., Morrison A. B. A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats. Am J Pathol. 1975 Apr;79(1):95–106. [PMC free article] [PubMed] [Google Scholar]
  29. Wenzel S. E., Westcott J. Y., Smith H. R., Larsen G. L. Spectrum of prostanoid release after bronchoalveolar allergen challenge in atopic asthmatics and in control groups. An alteration in the ratio of bronchoconstrictive to bronchoprotective mediators. Am Rev Respir Dis. 1989 Feb;139(2):450–457. doi: 10.1164/ajrccm/139.2.450. [DOI] [PubMed] [Google Scholar]

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