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Indian Journal of Psychiatry logoLink to Indian Journal of Psychiatry
. 2000 Oct-Dec;42(4):397–401.

P300 EVENT RELATED POTENTIAL IN NORMAL HEALTHY CONTROLS OF DIFFERENT AGE GROUPS

R Shukla *,*, JK Trivedi †, R Singh ‡, Y Singh §, P Chakravorty
PMCID: PMC2962741  PMID: 21407977

Abstract

P300 event related potential was recorded in 115 healthy controls with a mean age of35.9±14.81 years and a male : female ratio of 72 : 43. There was significant difference in the P300 latency in < 40 years as compared to ≥ 40 years group (p< 0.001). There was no significant difference between males and females. There was a strong positive correlation between age and P300 latency (p< 0.001). The regression equation for P300 latency was Y=287.9+1.492x with an SEE of 20.2 (where Y is the P300 latency in ms, x is the age in years, SEE is the standard error of estimate). There was a negative correlation between age and P300 amplitude which was significant in ≥ 40 years age group while in > 40 years age group it was not significant.

Keywords: Event related potentials, P300

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Selected References

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  1. Beck E. C., Swanson C., Dustman R. E. Long latency components of the visually evoked potential in man: effects of aging. Exp Aging Res. 1980 Dec;6(6):523–545. doi: 10.1080/03610738008258385. [DOI] [PubMed] [Google Scholar]
  2. Duncan-Johnson C. C., Donchin E. On quantifying surprise: the variation of event-related potentials with subjective probability. Psychophysiology. 1977 Sep;14(5):456–467. doi: 10.1111/j.1469-8986.1977.tb01312.x. [DOI] [PubMed] [Google Scholar]
  3. Fein G., Turetsky B. P300 latency variability in normal elderly: effects of paradigm and measurement technique. Electroencephalogr Clin Neurophysiol. 1989 May;72(5):384–394. doi: 10.1016/0013-4694(89)90044-8. [DOI] [PubMed] [Google Scholar]
  4. Goodin D. S., Squires K. C., Henderson B. H., Starr A. Age-related variations in evoked potentials to auditory stimuli in normal human subjects. Electroencephalogr Clin Neurophysiol. 1978 Apr;44(4):447–458. doi: 10.1016/0013-4694(78)90029-9. [DOI] [PubMed] [Google Scholar]
  5. Halgren E., Squires N. K., Wilson C. L., Rohrbaugh J. W., Babb T. L., Crandall P. H. Endogenous potentials generated in the human hippocampal formation and amygdala by infrequent events. Science. 1980 Nov 14;210(4471):803–805. doi: 10.1126/science.7434000. [DOI] [PubMed] [Google Scholar]
  6. Ivey R. G., Schmidt H. B. P300 response: habituation. J Am Acad Audiol. 1993 May;4(3):182–188. [PubMed] [Google Scholar]
  7. Jha S., Shukla R., Nag D., Kar A. M., Agarwal A. Effect of age on P300 wave. J Assoc Physicians India. 1995 Jan;43(1):21–23. [PubMed] [Google Scholar]
  8. Johnson R., Jr Scalp-recorded P300 activity in patients following unilateral temporal lobectomy. Brain. 1988 Dec;111(Pt 6):1517–1529. doi: 10.1093/brain/111.6.1517. [DOI] [PubMed] [Google Scholar]
  9. Mitzdorf U. Properties of cortical generators of event-related potentials. Pharmacopsychiatry. 1994 Mar;27(2):49–51. doi: 10.1055/s-2007-1014274. [DOI] [PubMed] [Google Scholar]
  10. Pfefferbaum A., Ford J. M., Wenegrat B. G., Roth W. T., Kopell B. S. Clinical application of the P3 component of event-related potentials. I. Normal aging. Electroencephalogr Clin Neurophysiol. 1984 Apr;59(2):85–103. doi: 10.1016/0168-5597(84)90026-1. [DOI] [PubMed] [Google Scholar]
  11. Picton T. W., Stuss D. T., Champagne S. C., Nelson R. F. The effects of age on human event-related potentials. Psychophysiology. 1984 May;21(3):312–325. doi: 10.1111/j.1469-8986.1984.tb02941.x. [DOI] [PubMed] [Google Scholar]
  12. Raudino F. Event related potential (P300) and personality: a study of normal subjects. Funct Neurol. 1993 Jul-Aug;8(4):259–264. [PubMed] [Google Scholar]
  13. Sklare D. A., Lynn G. E. Latency of the P3 event-related potential: normative aspects and within-subject variability. Electroencephalogr Clin Neurophysiol. 1984 Sep;59(5):420–424. doi: 10.1016/0168-5597(84)90043-1. [DOI] [PubMed] [Google Scholar]
  14. Smith D. B., Michalewski H. J., Brent G. A., Thompson L. W. Auditory averaged evoked potentials and aging: factors of stimulus, task and topography. Biol Psychol. 1980 Sep;11(2):135–151. doi: 10.1016/0301-0511(80)90048-4. [DOI] [PubMed] [Google Scholar]
  15. Squires N. K., Squires K. C., Hillyard S. A. Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. Electroencephalogr Clin Neurophysiol. 1975 Apr;38(4):387–401. doi: 10.1016/0013-4694(75)90263-1. [DOI] [PubMed] [Google Scholar]
  16. Sutton S., Braren M., Zubin J., John E. R. Evoked-potential correlates of stimulus uncertainty. Science. 1965 Nov 26;150(3700):1187–1188. doi: 10.1126/science.150.3700.1187. [DOI] [PubMed] [Google Scholar]
  17. Tandon O. P. P3 event-related evoked potential in young adults. Indian J Physiol Pharmacol. 1990 Jul;34(3):191–194. [PubMed] [Google Scholar]

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