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. 1994 Jul;94(1):413–417. doi: 10.1172/JCI117338

Taxol arrests the development of blood-stage Plasmodium falciparum in vitro and Plasmodium chabaudi adami in malaria-infected mice.

B Pouvelle 1, P J Farley 1, C A Long 1, T F Taraschi 1
PMCID: PMC296324  PMID: 7913713

Abstract

Taxol, a natural product used to treat a variety of human cancers, is shown here to be extremely effective against chloroquine- and pyrimethamine-resistant malaria parasites. Addition of Taxol (1.0 microM) for one cycle to cultures of human erythrocytes infected with Plasmodium falciparum prevents the establishment of new infections. Blood parasitemia is eliminated in mice infected with Plasmodium chabaudi adami when they are given a single intraperitoneal injection of Taxol at 150 mg/m2. The majority of the animals treated immediately preceding parasite schizogony remain free of infection after eight replication cycles. The impressive antimalarial activity of Taxol, at a dosage that has been tolerated in humans, establishes its potential utility for treatment of severe, drug-resistant human malaria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bissery M. C., Guénard D., Guéritte-Voegelein F., Lavelle F. Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue. Cancer Res. 1991 Sep 15;51(18):4845–4852. [PubMed] [Google Scholar]
  2. Bray R. S., Garnham P. C. The life-cycle of primate malaria parasites. Br Med Bull. 1982 May;38(2):117–122. doi: 10.1093/oxfordjournals.bmb.a071746. [DOI] [PubMed] [Google Scholar]
  3. Freireich E. J., Gehan E. A., Rall D. P., Schmidt L. H., Skipper H. E. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother Rep. 1966 May;50(4):219–244. [PubMed] [Google Scholar]
  4. Gormley J. A., Howard R. J., Taraschi T. F. Trafficking of malarial proteins to the host cell cytoplasm and erythrocyte surface membrane involves multiple pathways. J Cell Biol. 1992 Dec;119(6):1481–1495. doi: 10.1083/jcb.119.6.1481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kumar N., Aikawa M., Grotendorst C. Plasmodium gallinaceum: critical role for microtubules in the transformation of zygotes into Ookinetes. Exp Parasitol. 1985 Apr;59(2):239–247. doi: 10.1016/0014-4894(85)90078-5. [DOI] [PubMed] [Google Scholar]
  6. Lambros C., Vanderberg J. P. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol. 1979 Jun;65(3):418–420. [PubMed] [Google Scholar]
  7. Pouvelle B., Spiegel R., Hsiao L., Howard R. J., Morris R. L., Thomas A. P., Taraschi T. F. Direct access to serum macromolecules by intraerythrocytic malaria parasites. Nature. 1991 Sep 5;353(6339):73–75. doi: 10.1038/353073a0. [DOI] [PubMed] [Google Scholar]
  8. Read M., Sherwin T., Holloway S. P., Gull K., Hyde J. E. Microtubular organization visualized by immunofluorescence microscopy during erythrocytic schizogony in Plasmodium falciparum and investigation of post-translational modifications of parasite tubulin. Parasitology. 1993 Apr;106(Pt 3):223–232. doi: 10.1017/s0031182000075041. [DOI] [PubMed] [Google Scholar]
  9. Rowinsky E. K., Cazenave L. A., Donehower R. C. Taxol: a novel investigational antimicrotubule agent. J Natl Cancer Inst. 1990 Aug 1;82(15):1247–1259. doi: 10.1093/jnci/82.15.1247. [DOI] [PubMed] [Google Scholar]
  10. Schiff P. B., Fant J., Horwitz S. B. Promotion of microtubule assembly in vitro by taxol. Nature. 1979 Feb 22;277(5698):665–667. doi: 10.1038/277665a0. [DOI] [PubMed] [Google Scholar]
  11. Schiff P. B., Horwitz S. B. Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1561–1565. doi: 10.1073/pnas.77.3.1561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Shaw M. K., Tilney L. G. How individual cells develop from a syncytium: merogony in Theileria parva (Apicomplexa). J Cell Sci. 1992 Jan;101(Pt 1):109–123. doi: 10.1242/jcs.101.1.109. [DOI] [PubMed] [Google Scholar]
  13. Wani M. C., Taylor H. L., Wall M. E., Coggon P., McPhail A. T. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc. 1971 May 5;93(9):2325–2327. doi: 10.1021/ja00738a045. [DOI] [PubMed] [Google Scholar]
  14. Wiernik P. H., Schwartz E. L., Einzig A., Strauman J. J., Lipton R. B., Dutcher J. P. Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma. J Clin Oncol. 1987 Aug;5(8):1232–1239. doi: 10.1200/JCO.1987.5.8.1232. [DOI] [PubMed] [Google Scholar]
  15. Wiernik P. H., Schwartz E. L., Strauman J. J., Dutcher J. P., Lipton R. B., Paietta E. Phase I clinical and pharmacokinetic study of taxol. Cancer Res. 1987 May 1;47(9):2486–2493. [PubMed] [Google Scholar]
  16. Zhang Y., Asante K. S., Jung A. Stage-dependent inhibition of chloroquine on Plasmodium falciparum in vitro. J Parasitol. 1986 Dec;72(6):830–836. [PubMed] [Google Scholar]

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