Skip to main content
. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Neuropharmacology. 2010 Sep 8;59(7-8):573–581. doi: 10.1016/j.neuropharm.2010.08.017

Fig. 8. Inhibition of fully kindled seizures and afterdischarge duration by P in WT (A) and PRKO mice (B).

Fig. 8

Animals were stimulated daily and were used when they exhibited fully kindled (stage 5) seizures on three consecutive days. Vehicle or P was injected subcutaneously 30 min before stimulation. Percent inhibition of seizure stage was calculated as 100 × (1−S/5), where S is the seizure stage following drug treatment. Percentage inhibition of afterdischarge was calculated as 100 × (1−D/Dc), where D is the afterdischarge duration after drug treatment and Dc is the average control afterdischarge duration without any drug treatment. The overall mean control AD duration was 31±4 and 26 ±4 s in WT and PRKO mice, respectively. Each bar represents the mean ± SEM (n = 6–8 mice per group). *p<0.01 vs. control.