Abstract
Primary hypersomnia, a rare clinical syndrome, was diagnosed in a 14-year-old boy. The syndrome showed partial response to high dose fluoxetine therapy (120 mg/day) which recruited insomnia, an adverse effect of the drug, for therapeutic purposes. Response was enhanced with intermittent methylphenidate in association with a lower dose of fluoxetine. A possible pharmacokinetic interaction developed, comprising fluoxetine-induced augmentation of methylphenidate activity; such an interaction has not been previously reported.
Keywords: Primary hypersomnia, hypersomnia, Narcolepsy, fluoxetine, methylphenidate, drug interaction, pharmacokinetic interaction
Full Text
The Full Text of this article is available as a PDF (198.9 KB).