Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1990 Feb;85(2):311–315. doi: 10.1172/JCI114439

Biological markers for increased risk of alcoholism and for quantitation of alcohol consumption.

D W Crabb 1
PMCID: PMC296425  PMID: 2298906

Full text

PDF
311

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexopoulos G. S., Lieberman K. W., Frances R. J. Platelet MAO activity in alcoholic patients and their first-degree relatives. Am J Psychiatry. 1983 Nov;140(11):1501–1504. doi: 10.1176/ajp.140.11.1501. [DOI] [PubMed] [Google Scholar]
  2. Bach A. W., Lan N. C., Johnson D. L., Abell C. W., Bembenek M. E., Kwan S. W., Seeburg P. H., Shih J. C. cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4934–4938. doi: 10.1073/pnas.85.13.4934. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Begleiter H., Porjesz B., Bihari B., Kissin B. Event-related brain potentials in boys at risk for alcoholism. Science. 1984 Sep 28;225(4669):1493–1496. doi: 10.1126/science.6474187. [DOI] [PubMed] [Google Scholar]
  4. Begleiter H., Porjesz B., Chou C. L. Auditory brainstem potentials in chronic alcoholics. Science. 1981 Mar 6;211(4486):1064–1066. doi: 10.1126/science.7466379. [DOI] [PubMed] [Google Scholar]
  5. Begleiter H., Porjesz B. Potential biological markers in individuals at high risk for developing alcoholism. Alcohol Clin Exp Res. 1988 Aug;12(4):488–493. doi: 10.1111/j.1530-0277.1988.tb00231.x. [DOI] [PubMed] [Google Scholar]
  6. Behrens U. J., Hoerner M., Lasker J. M., Lieber C. S. Formation of acetaldehyde adducts with ethanol-inducible P450IIE1 in vivo. Biochem Biophys Res Commun. 1988 Jul 29;154(2):584–590. doi: 10.1016/0006-291x(88)90180-5. [DOI] [PubMed] [Google Scholar]
  7. Behrens U. J., Worner T. M., Braly L. F., Schaffner F., Lieber C. S. Carbohydrate-deficient transferrin, a marker for chronic alcohol consumption in different ethnic populations. Alcohol Clin Exp Res. 1988 Jun;12(3):427–432. doi: 10.1111/j.1530-0277.1988.tb00221.x. [DOI] [PubMed] [Google Scholar]
  8. Bohman M. Some genetic aspects of alcoholism and criminality. A population of adoptees. Arch Gen Psychiatry. 1978 Mar;35(3):269–276. doi: 10.1001/archpsyc.1978.01770270019001. [DOI] [PubMed] [Google Scholar]
  9. Bosron W. F., Rex D. K., Harden C. A., Li T. K., Akerson R. D. Alcohol and aldehyde dehydrogenase isoenzymes in Sioux North American Indians. Alcohol Clin Exp Res. 1988 Jun;12(3):454–455. doi: 10.1111/j.1530-0277.1988.tb00225.x. [DOI] [PubMed] [Google Scholar]
  10. Cloninger C. R., Bohman M., Sigvardsson S. Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Arch Gen Psychiatry. 1981 Aug;38(8):861–868. doi: 10.1001/archpsyc.1981.01780330019001. [DOI] [PubMed] [Google Scholar]
  11. Cloninger C. R. Neurogenetic adaptive mechanisms in alcoholism. Science. 1987 Apr 24;236(4800):410–416. doi: 10.1126/science.2882604. [DOI] [PubMed] [Google Scholar]
  12. Crabb D. W., Bosron W. F., Li T. K. Ethanol metabolism. Pharmacol Ther. 1987;34(1):59–73. doi: 10.1016/0163-7258(87)90092-1. [DOI] [PubMed] [Google Scholar]
  13. Crabb D. W., Edenberg H. J., Bosron W. F., Li T. K. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. J Clin Invest. 1989 Jan;83(1):314–316. doi: 10.1172/JCI113875. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Diamond I., Wrubel B., Estrin W., Gordon A. Basal and adenosine receptor-stimulated levels of cAMP are reduced in lymphocytes from alcoholic patients. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1413–1416. doi: 10.1073/pnas.84.5.1413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Fowler C. J., Tipton K. F., MacKay A. V., Youdim M. B. Human platelet monoamine oxidase--a useful enzyme in the study of psychiatric disorders? Neuroscience. 1982 Jul;7(7):1577–1594. doi: 10.1016/0306-4522(82)90016-1. [DOI] [PubMed] [Google Scholar]
  16. Gottfries C. G., Oreland L., Wiberg A., Winblad B. Lowered monoamine oxidase activity in brains from alcoholic suicides. J Neurochem. 1975 Nov;25(5):667–673. doi: 10.1111/j.1471-4159.1975.tb04386.x. [DOI] [PubMed] [Google Scholar]
  17. Harada S., Agarwal D. P., Goedde H. W., Ishikawa B. Aldehyde dehydrogenase isozyme variation and alcoholism in Japan. Pharmacol Biochem Behav. 1983;18 (Suppl 1):151–153. doi: 10.1016/0091-3057(83)90163-6. [DOI] [PubMed] [Google Scholar]
  18. Harada S., Agarwal D. P., Goedde H. W., Tagaki S., Ishikawa B. Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan. Lancet. 1982 Oct 9;2(8302):827–827. doi: 10.1016/s0140-6736(82)92722-2. [DOI] [PubMed] [Google Scholar]
  19. Hsu L. C., Bendel R. E., Yoshida A. Direct detection of usual and atypical alleles on the human aldehyde dehydrogenase-2 (ALDH2) locus. Am J Hum Genet. 1987 Dec;41(6):996–1001. [PMC free article] [PubMed] [Google Scholar]
  20. Kochersperger L. M., Parker E. L., Siciliano M., Darlington G. J., Denney R. M. Assignment of genes for human monoamine oxidases A and B to the X chromosome. J Neurosci Res. 1986;16(4):601–616. doi: 10.1002/jnr.490160403. [DOI] [PubMed] [Google Scholar]
  21. Lin R. C., Smith R. S., Lumeng L. Detection of a protein-acetaldehyde adduct in the liver of rats fed alcohol chronically. J Clin Invest. 1988 Feb;81(2):615–619. doi: 10.1172/JCI113362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Lumeng L., Durant P. J. Regulation of the formation of stable adducts between acetaldehyde and blood proteins. Alcohol. 1985 May-Jun;2(3):397–400. doi: 10.1016/0741-8329(85)90102-8. [DOI] [PubMed] [Google Scholar]
  23. Lumeng L. New diagnostic markers of alcohol abuse. Hepatology. 1986 Jul-Aug;6(4):742–745. doi: 10.1002/hep.1840060434. [DOI] [PubMed] [Google Scholar]
  24. Major L. F., Murphy D. L. Platelet and plasma amine oxidase activity in alcoholic individuals. Br J Psychiatry. 1978 Jun;132:548–554. doi: 10.1192/bjp.132.6.548. [DOI] [PubMed] [Google Scholar]
  25. Mayfield D., McLeod G., Hall P. The CAGE questionnaire: validation of a new alcoholism screening instrument. Am J Psychiatry. 1974 Oct;131(10):1121–1123. doi: 10.1176/ajp.131.10.1121. [DOI] [PubMed] [Google Scholar]
  26. McBride W. J., Murphy J. M., Lumeng L., Li T. K. Serotonin and ethanol preference. Recent Dev Alcohol. 1989;7:187–209. doi: 10.1007/978-1-4899-1678-5_10. [DOI] [PubMed] [Google Scholar]
  27. Nagy L. E., Diamond I., Gordon A. Cultured lymphocytes from alcoholic subjects have altered cAMP signal transduction. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6973–6976. doi: 10.1073/pnas.85.18.6973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Niemelä O., Klajner F., Orrego H., Vidins E., Blendis L., Israel Y. Antibodies against acetaldehyde-modified protein epitopes in human alcoholics. Hepatology. 1987 Nov-Dec;7(6):1210–1214. doi: 10.1002/hep.1840070607. [DOI] [PubMed] [Google Scholar]
  29. O'Connor S., Hesselbrock V., Tasman A. Correlates of increased risk for alcoholism in young men. Prog Neuropsychopharmacol Biol Psychiatry. 1986;10(2):211–218. doi: 10.1016/0278-5846(86)90075-8. [DOI] [PubMed] [Google Scholar]
  30. Pandey G. N., Fawcett J., Gibbons R., Clark D. C., Davis J. M. Platelet monoamine oxidase in alcoholism. Biol Psychiatry. 1988 May;24(1):15–24. doi: 10.1016/0006-3223(88)90117-5. [DOI] [PubMed] [Google Scholar]
  31. Skinner H. A., Holt S., Schuller R., Roy J., Israel Y. Identification of alcohol abuse using laboratory tests and a history of trauma. Ann Intern Med. 1984 Dec;101(6):847–851. doi: 10.7326/0003-4819-101-6-847. [DOI] [PubMed] [Google Scholar]
  32. Stevens V. J., Fantl W. J., Newman C. B., Sims R. V., Cerami A., Peterson C. M. Acetaldehyde adducts with hemoglobin. J Clin Invest. 1981 Feb;67(2):361–369. doi: 10.1172/JCI110043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Stibler H., Allgulander C., Borg S., Kjellin K. G. Abnormal microheterogeneity of transferrin in serum and cerebrospinal fluid in alcoholism. Acta Med Scand. 1978;204(1-2):49–56. doi: 10.1111/j.0954-6820.1978.tb08397.x. [DOI] [PubMed] [Google Scholar]
  34. Stibler H., Borg S., Allgulander C. Clinical significance of abnormal heterogeneity of transferrin in relation to alcohol consumption. Acta Med Scand. 1979;206(4):275–281. doi: 10.1111/j.0954-6820.1979.tb13510.x. [DOI] [PubMed] [Google Scholar]
  35. Sullivan J. L., Cavenar J. O., Jr, Maltbie A. A., Lister P., Zung W. W. Familial biochemical and clinical correlates of alcoholics with low platelet monoamine oxidase activity. Biol Psychiatry. 1979 Apr;14(2):385–394. [PubMed] [Google Scholar]
  36. Sullivan J. L., Stanfield C. N., Maltbie A. A., Hammett E., Cavenar J. O., Jr Stability of low blood platelet monoamine oxidase activity in human alcoholics. Biol Psychiatry. 1978 Jun;13(3):391–397. [PubMed] [Google Scholar]
  37. Tabakoff B., Hoffman P. L., Lee J. M., Saito T., Willard B., De Leon-Jones F. Differences in platelet enzyme activity between alcoholics and nonalcoholics. N Engl J Med. 1988 Jan 21;318(3):134–139. doi: 10.1056/NEJM198801213180302. [DOI] [PubMed] [Google Scholar]
  38. Tuma D. J., Jennett R. B., Sorrell M. F. The interaction of acetaldehyde with tubulin. Ann N Y Acad Sci. 1987;492:277–286. doi: 10.1111/j.1749-6632.1987.tb48681.x. [DOI] [PubMed] [Google Scholar]
  39. Watson R. R., Mohs M. E., Eskelson C., Sampliner R. E., Hartmann B. Identification of alcohol abuse and alcoholism with biological parameters. Alcohol Clin Exp Res. 1986 Aug;10(4):364–385. doi: 10.1111/j.1530-0277.1986.tb05108.x. [DOI] [PubMed] [Google Scholar]
  40. Westlund K. N., Denney R. M., Kochersperger L. M., Rose R. M., Abell C. W. Distinct monoamine oxidase A and B populations in primate brain. Science. 1985 Oct 11;230(4722):181–183. doi: 10.1126/science.3875898. [DOI] [PubMed] [Google Scholar]
  41. Xu Y. L., Carr L. G., Bosron W. F., Li T. K., Edenberg H. J. Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics. 1988 Apr;2(3):209–214. doi: 10.1016/0888-7543(88)90004-3. [DOI] [PubMed] [Google Scholar]
  42. Yoshida A., Huang I. Y., Ikawa M. Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci U S A. 1984 Jan;81(1):258–261. doi: 10.1073/pnas.81.1.258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Yoshihara H., Sato N., Kamada T., Abe H. Low Km ALDH isozyme and alcoholic liver injury. Pharmacol Biochem Behav. 1983;18 (Suppl 1):425–428. doi: 10.1016/0091-3057(83)90211-3. [DOI] [PubMed] [Google Scholar]
  44. von Knorring A. L., Bohman M., von Knorring L., Oreland L. Platelet MAO activity as a biological marker in subgroups of alcoholism. Acta Psychiatr Scand. 1985 Jul;72(1):51–58. doi: 10.1111/j.1600-0447.1985.tb02570.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES