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Indian Journal of Psychiatry logoLink to Indian Journal of Psychiatry
. 1998 Jan-Mar;40(1):60–66.

ACTIVE PLATELET 5-HT UPTAKE IN DEPRESSIVES TREATED WITH IMPRAMINE AND ECT

PK Dalal *,*, Narottam Lal 2, JK Trivedi 3, PK Seth 1, AK Agarwal 1, Abdul Khalid 6
PMCID: PMC2964820  PMID: 21494445

Abstract

Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patients of major depression and equal number of age and sex-matched controls were included in the study. The depressives received imipramine (N=15) or ECT (N=15). Pretreatment active platelet 5-HT uptake was lower in depressives. Treatment with imipramine resulted in significant decrease in 5-HT uptake while with ECT there was significant increase. The serotonergic mechanisms are discussed.

Keywords: Active platelet 5-HT uptake, major depression, imipramine, ECT

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Selected References

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