FIG. 2.
(a) Flow chart showing the organs considered in this work; gray organs were included in the model but not measured in the experiment. (b) Schematic of a typical organ as part of the physiologically based model. C, concentration of the compound (μg/g); V, volume (ml); Q, flow rate (ml/hour); PS, permeability surface area product (ml/hour); Kpu, extravascular tissue/unbound plasma partition coefficient; T,V, vascular part of a given tissue; T,EV, extravascular part of a given tissue; Cven, concentration in venous compartment; Cart, concentration in arterial compartment.