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. 1997 Jan-Mar;39(1):41–48.

CSF 5 - HIAA IN VIOLENT AND NON-VIOLENT SUICIDE ATTEMPTERS

JK Trivedi *,*, Sunil Pandey †, PK Dalal ‡, MP Dubey §, PK Sinha
PMCID: PMC2967082  PMID: 21584043

Abstract

Many studies have reported involvement of monoamine neurotransmission in suicide through measurement of serotonin and its main metabolite, 5-HIAA, in brain of suicide victims and in CSF of suicide attempters. 23 non-depressed non-psychotic suicide attempters and equal number of controls were selected, and all the subjects were screened on Cornell Medical Index. Suicide attempters were assessed on Risk-Rescue Rating Scale and were divided into non-violent suicide attempters (N= 12) and violent suicide attempters (N= II). CSF of all subjects was collected by lumbar puncture and CSF 5-HIAA was measured by high performance liquid chromatography with electro-chemical detector. Risk-rescue rating score was significantly higher in violent suicide attempters as compared to non-violent suicide attempters. Mean CSF- 5- HIAA was significantly lower in suicide attempters as compared to normal controls. Mean CSF 5-HIAA was significantly lower in violent suicide attempters as compared to non-violent suicide attempters.

Keywords: CSF 5-HIAA, suicide, non-violent suicide attempters, violent suicide attempters

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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