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Indian Journal of Psychiatry logoLink to Indian Journal of Psychiatry
. 1997 Oct-Dec;39(4):272–277.

ECT AND PLATELET 5HT UPTAKE IN MAJOR DEPRESSION

PK Dalal *,*, Narottam Lal †, JK Trivedi ‡, PK Seth §, AK Agarwal , Abdul Khalid #
PMCID: PMC2967157  PMID: 21584091

Abstract

Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The mechanism of antidepressant action of ECT is not clear. The present work was undertaken with the aim to study the active platelet 5-HT uptake and the effect of ECT on it in patients of major depression. 15 patients of major depression (DSM-lll-R) and equal number of age and sex-matched controls were included in the study. Active platelet 5-HT uptake was determined before ECT, after a course of ECT and 7 days after last ECT. Platelet 5-HT uptake was. significantly lower in der essives than normal controls. After ECT treatment there was significant increase in 5-HT uptake which came down to pretreatment level after 1 week of last ECT. The effect of ECT on serotonergic system is discussed.

Keywords: Active platelet 5-HT uptake, major depression, ECT, serotonin

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Selected References

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