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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Hepatology. 2010 Nov;52(5):1750–1757. doi: 10.1002/hep.23880

Figure 2A. EFFECT OF AGE ON DEGREE OF OVAL CELL RESPONSE OF LIVER TO CD-ETHIONINE.

Figure 2A

Histologic grading of oval cell reaction in liver (20X). 0. Normal 4 month old liver; 1, Grade 1; 2, Grade 2; 3, Grade 3; 4, Grade 4; 5, Grade 5. In A, small round cells are limited to the portal plate. Grades 1 and 2 show short extension of cords of small oval cells into the hepatic parenchyma. Grades 3 thorough 5 show increasing replacement of the normal hepatocytes with small oval cells. In livers with grade 5 lesions up to 80% of the liver may be replaced by oval cells. The bars show the average grade for the rats from each group; the numbers at the top of the bars indicate the number of animals examined.