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. 1990 Oct;86(4):1369–1374. doi: 10.1172/JCI114849

In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat.

C Cavard 1, A Zider 1, M Vernet 1, M Bennoun 1, S Saragosti 1, G Grimber 1, P Briand 1
PMCID: PMC296873  PMID: 2120288

Abstract

It has been previously shown in vitro that the human immunodeficiency virus type 1 long terminal repeat (LTR) is activated by ultraviolet irradiation. In order to analyze if a similar effect could occur in vivo, transgenic mice carrying the lacZ gene under the control of the viral LTR were irradiated at 280-300 and 254 nm. These mice spontaneously expressed the transgene in the epidermis and the lens of both adults and embryos. Irradiations caused a significant increase in skin beta-galactosidase activity. This phenomenon might be involved in viral activation and could be of interest in regard to the skin pathology observed during an HIV infection.

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Selected References

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