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. 1990 Nov;86(5):1381–1386. doi: 10.1172/JCI114851

Antibiotic proteins of human neutrophils.

J K Spitznagel 1
PMCID: PMC296879  PMID: 2243118

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bangalore N., Travis J., Onunka V. C., Pohl J., Shafer W. M. Identification of the primary antimicrobial domains in human neutrophil cathepsin G. J Biol Chem. 1990 Aug 15;265(23):13584–13588. [PubMed] [Google Scholar]
  2. Campanelli D., Detmers P. A., Nathan C. F., Gabay J. E. Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties. J Clin Invest. 1990 Mar;85(3):904–915. doi: 10.1172/JCI114518. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Daher K. A., Lehrer R. I., Ganz T., Kronenberg M. Isolation and characterization of human defensin cDNA clones. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7327–7331. doi: 10.1073/pnas.85.19.7327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Farley M. M., Shafer W. M., Spitznagel J. K. Lipopolysaccharide structure determines ionic and hydrophobic binding of a cationic antimicrobial neutrophil granule protein. Infect Immun. 1988 Jun;56(6):1589–1592. doi: 10.1128/iai.56.6.1589-1592.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gabay J. E., Scott R. W., Campanelli D., Griffith J., Wilde C., Marra M. N., Seeger M., Nathan C. F. Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5610–5614. doi: 10.1073/pnas.86.14.5610. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ganz T. Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes. Infect Immun. 1987 Mar;55(3):568–571. doi: 10.1128/iai.55.3.568-571.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ganz T., Metcalf J. A., Gallin J. I., Boxer L. A., Lehrer R. I. Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency. J Clin Invest. 1988 Aug;82(2):552–556. doi: 10.1172/JCI113631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gray P. W., Flaggs G., Leong S. R., Gumina R. J., Weiss J., Ooi C. E., Elsbach P. Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations. J Biol Chem. 1989 Jun 5;264(16):9505–9509. [PubMed] [Google Scholar]
  9. Greenwald G. I., Ganz T. Defensins mediate the microbicidal activity of human neutrophil granule extract against Acinetobacter calcoaceticus. Infect Immun. 1987 Jun;55(6):1365–1368. doi: 10.1128/iai.55.6.1365-1368.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Holmes B., Page A. R., Good R. A. Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function. J Clin Invest. 1967 Sep;46(9):1422–1432. doi: 10.1172/JCI105634. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hovde C. J., Gray B. H. Characterization of a protein from normal human polymorphonuclear leukocytes with bactericidal activity against Pseudomonas aeruginosa. Infect Immun. 1986 Oct;54(1):142–148. doi: 10.1128/iai.54.1.142-148.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hovde C. J., Gray B. H. Physiological effects of a bactericidal protein from human polymorphonuclear leukocytes on Pseudomonas aeruginosa. Infect Immun. 1986 Apr;52(1):90–95. doi: 10.1128/iai.52.1.90-95.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kagan B. L., Selsted M. E., Ganz T., Lehrer R. I. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci U S A. 1990 Jan;87(1):210–214. doi: 10.1073/pnas.87.1.210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Lehrer R. I., Barton A., Daher K. A., Harwig S. S., Ganz T., Selsted M. E. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest. 1989 Aug;84(2):553–561. doi: 10.1172/JCI114198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Mannion B. A., Kalatzis E. S., Weiss J., Elsbach P. Preferential binding of the neutrophil cytoplasmic granule-derived bactericidal/permeability increasing protein to target bacteria. Implications and use as a means of purification. J Immunol. 1989 Apr 15;142(8):2807–2812. [PubMed] [Google Scholar]
  16. Marra M. N., Wilde C. G., Griffith J. E., Snable J. L., Scott R. W. Bactericidal/permeability-increasing protein has endotoxin-neutralizing activity. J Immunol. 1990 Jan 15;144(2):662–666. [PubMed] [Google Scholar]
  17. Ooi C. E., Weiss J., Elsbach P., Frangione B., Mannion B. A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein. J Biol Chem. 1987 Nov 5;262(31):14891–14894. [PubMed] [Google Scholar]
  18. Pereira H. A., Shafer W. M., Pohl J., Martin L. E., Spitznagel J. K. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. J Clin Invest. 1990 May;85(5):1468–1476. doi: 10.1172/JCI114593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Pereira H. A., Spitznagel J. K., Pohl J., Wilson D. E., Morgan J., Palings I., Larrick J. W. CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases. Life Sci. 1990;46(3):189–196. doi: 10.1016/0024-3205(90)90104-y. [DOI] [PubMed] [Google Scholar]
  20. Rotrosen D., Gallin J. I. Disorders of phagocyte function. Annu Rev Immunol. 1987;5:127–150. doi: 10.1146/annurev.iy.05.040187.001015. [DOI] [PubMed] [Google Scholar]
  21. Salvesen G., Farley D., Shuman J., Przybyla A., Reilly C., Travis J. Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases. Biochemistry. 1987 Apr 21;26(8):2289–2293. doi: 10.1021/bi00382a032. [DOI] [PubMed] [Google Scholar]
  22. Selsted M. E., Harwig S. S. Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide. J Biol Chem. 1989 Mar 5;264(7):4003–4007. [PubMed] [Google Scholar]
  23. Shafer W. M., Engle S. A., Martin L. E., Spitznagel J. K. Killing of Proteus mirabilis by polymorphonuclear leukocyte granule proteins: evidence for species specificity by antimicrobial proteins. Infect Immun. 1988 Jan;56(1):51–53. doi: 10.1128/iai.56.1.51-53.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Shafer W. M., Martin L. E., Spitznagel J. K. Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate. Infect Immun. 1984 Jul;45(1):29–35. doi: 10.1128/iai.45.1.29-35.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Shafer W. M., Martin L. E., Spitznagel J. K. Late intraphagosomal hydrogen ion concentration favors the in vitro antimicrobial capacity of a 37-kilodalton cationic granule protein of human neutrophil granulocytes. Infect Immun. 1986 Sep;53(3):651–655. doi: 10.1128/iai.53.3.651-655.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Shafer W. M., Onunka V. C., Martin L. E. Antigonococcal activity of human neutrophil cathepsin G. Infect Immun. 1986 Oct;54(1):184–188. doi: 10.1128/iai.54.1.184-188.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Shafer W. M., Onunka V. C. Mechanism of staphylococcal resistance to non-oxidative antimicrobial action of neutrophils: importance of pH and ionic strength in determining the bactericidal action of cathepsin G. J Gen Microbiol. 1989 Apr;135(4):825–830. doi: 10.1099/00221287-135-4-825. [DOI] [PubMed] [Google Scholar]
  28. Sparkes R. S., Kronenberg M., Heinzmann C., Daher K. A., Klisak I., Ganz T., Mohandas T. Assignment of defensin gene(s) to human chromosome 8p23. Genomics. 1989 Aug;5(2):240–244. doi: 10.1016/0888-7543(89)90052-9. [DOI] [PubMed] [Google Scholar]
  29. Spitznagel J. K. Nonoxidative antimicrobial reactions of leukocytes. Contemp Top Immunobiol. 1984;14:283–343. doi: 10.1007/978-1-4757-4862-8_10. [DOI] [PubMed] [Google Scholar]
  30. Spitznagel J. K., Pereira H. A., Martin L. E., Guzman G. S., Shafer W. M. A monoclonal antibody that inhibits the antimicrobial action of a 57 KD cationic protein of human polymorphonuclear leukocytes. J Immunol. 1987 Aug 15;139(4):1291–1296. [PubMed] [Google Scholar]
  31. Stanfield R. L., Westbrook E. M., Selsted M. E. Characterization of two crystal forms of human defensin neutrophil cationic peptide 1, a naturally occurring antimicrobial peptide of leukocytes. J Biol Chem. 1988 Apr 25;263(12):5933–5935. [PubMed] [Google Scholar]
  32. Stinavage P., Martin L. E., Spitznagel J. K. O antigen and lipid A phosphoryl groups in resistance of Salmonella typhimurium LT-2 to nonoxidative killing in human polymorphonuclear neutrophils. Infect Immun. 1989 Dec;57(12):3894–3900. doi: 10.1128/iai.57.12.3894-3900.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Territo M. C., Ganz T., Selsted M. E., Lehrer R. Monocyte-chemotactic activity of defensins from human neutrophils. J Clin Invest. 1989 Dec;84(6):2017–2020. doi: 10.1172/JCI114394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Tobias P. S., Mathison J. C., Ulevitch R. J. A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis. J Biol Chem. 1988 Sep 25;263(27):13479–13481. [PubMed] [Google Scholar]
  35. Viljanen P., Koski P., Vaara M. Effect of small cationic leukocyte peptides (defensins) on the permeability barrier of the outer membrane. Infect Immun. 1988 Sep;56(9):2324–2329. doi: 10.1128/iai.56.9.2324-2329.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Weiss J., Kao L., Victor M., Elsbach P. Oxygen-independent intracellular and oxygen-dependent extracellular killing of Escherichia coli S15 by human polymorphonuclear leukocytes. J Clin Invest. 1985 Jul;76(1):206–212. doi: 10.1172/JCI111947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Weiss J., Muello K., Victor M., Elsbach P. The role of lipopolysaccharides in the action of the bactericidal/permeability-increasing neutrophil protein on the bacterial envelope. J Immunol. 1984 Jun;132(6):3109–3115. [PubMed] [Google Scholar]
  38. Weiss J., Olsson I. Cellular and subcellular localization of the bactericidal/permeability-increasing protein of neutrophils. Blood. 1987 Feb;69(2):652–659. [PubMed] [Google Scholar]
  39. Wilde C. G., Griffith J. E., Marra M. N., Snable J. L., Scott R. W. Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J Biol Chem. 1989 Jul 5;264(19):11200–11203. [PubMed] [Google Scholar]

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