Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1990 Nov;86(5):1532–1539. doi: 10.1172/JCI114872

Angiotensin and thromboxane in the enhanced renal adrenergic nerve sensitivity of acute renal failure.

J B Robinette 1, J D Conger 1
PMCID: PMC296900  PMID: 2243129

Abstract

The roles of intrarenal angiotensin (A) and thromboxane (TX) in the vascular hypersensitivity to renal nerve stimulation (RNS) and paradoxical vasoconstriction to renal perfusion pressure (RPP) reduction in the autoregulatory range in 1 wk norepinephrine (NE)-induced acute renal failure (ARF) in rats were investigated. Renal blood flow (RBF) responses were determined before and during intrarenal infusion of an AII and TXA2 antagonist. Saralasin or SQ29548 alone partially corrected the slopes of RBF to RNS and RPP reduction in NE-ARF rats (P less than 0.02). Saralasin + SQ29548 normalized the RBF response to RNS. While combined saralasin + SQ29548 eliminated the vasoconstriction to RPP reduction, similar to the effect of renal denervation, appropriate vasodilatation was not restored. Renal vein norepinephrine efflux during RNS was disproportionately increased in NE-ARF (P less than 0.001) and was suppressed by saralasin + SQ29548 infusion (P less than 0.005). It is concluded that the enhanced sensitivity to RNS and paradoxical vasoconstriction to RPP reduction in 1 wk NE-ARF kidneys are the result of intrarenal TX and AII acceleration of neurotransmitter release to adrenergic nerve activity.

Full text

PDF
1532

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams P. L., Adams F. F., Bell P. D., Navar L. G. Impaired renal blood flow autoregulation in ischemic acute renal failure. Kidney Int. 1980 Jul;18(1):68–76. doi: 10.1038/ki.1980.111. [DOI] [PubMed] [Google Scholar]
  2. Altiere R. J., Olson J. W., Gillespie M. N. Altered pulmonary vascular smooth muscle responsiveness in monocrotaline-induced pulmonary hypertension. J Pharmacol Exp Ther. 1986 Feb;236(2):390–395. [PubMed] [Google Scholar]
  3. Arendshorst W. J. Autoregulation of renal blood flow in spontaneously hypertensive rats. Circ Res. 1979 Mar;44(3):344–349. doi: 10.1161/01.res.44.3.344. [DOI] [PubMed] [Google Scholar]
  4. Brown J. J., Davies D. L., Lever A. F., Parker R. A., Robertson J. I. The assay of renin in single glomeruli and the appearance of the juxtaglomerular apparatus in the rabbit following renal artery constriction. Clin Sci. 1966 Apr;30(2):223–235. [PubMed] [Google Scholar]
  5. Conger J. D., Burke T. J. Effects of anesthetic agents on autoregulation of renal hemodynamics in the rat and dog. Am J Physiol. 1976 Mar;230(3):652–657. doi: 10.1152/ajplegacy.1976.230.3.652. [DOI] [PubMed] [Google Scholar]
  6. Conger J. D., Robinette J. B., Guggenheim S. J. Effect of acetylcholine on the early phase of reversible norepinephrine-induced acute renal failure. Kidney Int. 1981 Mar;19(3):399–409. doi: 10.1038/ki.1981.32. [DOI] [PubMed] [Google Scholar]
  7. Conger J. D., Robinette J. B., Kelleher S. P. Nephron heterogeneity in ischemic acute renal failure. Kidney Int. 1984 Oct;26(4):422–429. doi: 10.1038/ki.1984.191. [DOI] [PubMed] [Google Scholar]
  8. Conger J. D., Robinette J. B., Schrier R. W. Smooth muscle calcium and endothelium-derived relaxing factor in the abnormal vascular responses of acute renal failure. J Clin Invest. 1988 Aug;82(2):532–537. doi: 10.1172/JCI113628. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Conger J. D. Vascular abnormalities in the maintenance of acute renal failure. Circ Shock. 1983;11(3):235–244. [PubMed] [Google Scholar]
  10. Cox J. W., Baehler R. W., Sharma H., O'Dorisio T., Osgood R. W., Stein J. H., Ferris T. F. Studies of the mechanism of oliguria in a model of unilateral acute renal failure. J Clin Invest. 1974 Jun;53(6):1546–1558. doi: 10.1172/JCI107705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. DiBona G. F., Sawin L. L. The renin-angiotensin system in acute renal failure in the rat. Lab Invest. 1971 Dec;25(6):528–532. [PubMed] [Google Scholar]
  12. Fink G. D., Brody M. J. Impaired neurogenic control of renal vasculature in renal hypertensive rats. Am J Physiol. 1980 Jun;238(6):H770–H775. doi: 10.1152/ajpheart.1980.238.6.H770. [DOI] [PubMed] [Google Scholar]
  13. Hatziantoniou C., Papanikolaou N. Renal effects of the inhibitor of thromboxane A2-synthetase OKY-046. Experientia. 1986 Jun 15;42(6):613–615. doi: 10.1007/BF01955558. [DOI] [PubMed] [Google Scholar]
  14. Hughes J., Roth R. H. Evidence that angiotensin enhances transmitter release during sympathetic nerve stimulation. Br J Pharmacol. 1971 Feb;41(2):239–255. doi: 10.1111/j.1476-5381.1971.tb08025.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Jackson E. K., Uderman H. D., Herzer W. A., Branch R. A. Attenuation of noradrenergic neurotransmission by the thromboxane synthetase inhibitor, UK 38,485. Life Sci. 1984 Jul 9;35(2):221–228. doi: 10.1016/0024-3205(84)90143-7. [DOI] [PubMed] [Google Scholar]
  16. Johnson E. M., Jr, Marshall G. R., Needleman P. Modification of responses to sympathetic nerve stimulation by the renin-angiotensin system in rats. Br J Pharmacol. 1974 Aug;51(4):541–547. doi: 10.1111/j.1476-5381.1974.tb09672.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Kelleher S. P., Robinette J. B., Conger J. D. Sympathetic nervous system in the loss of autoregulation in acute renal failure. Am J Physiol. 1984 Apr;246(4 Pt 2):F379–F386. doi: 10.1152/ajprenal.1984.246.4.F379. [DOI] [PubMed] [Google Scholar]
  18. Kelleher S. P., Robinette J. B., Miller F., Conger J. D. Effect of hemorrhagic reduction in blood pressure on recovery from acute renal failure. Kidney Int. 1987 Mar;31(3):725–730. doi: 10.1038/ki.1987.58. [DOI] [PubMed] [Google Scholar]
  19. Kokot F., Kuska J. Plasma renin activity in acute renal insufficiency. Nephron. 1969;6(2):115–127. doi: 10.1159/000179720. [DOI] [PubMed] [Google Scholar]
  20. Matthys E., Patton M. K., Osgood R. W., Venkatachalam M. A., Stein J. H. Alterations in vascular function and morphology in acute ischemic renal failure. Kidney Int. 1983 May;23(5):717–724. doi: 10.1038/ki.1983.84. [DOI] [PubMed] [Google Scholar]
  21. Moss N. G. Electrophysiological characteristics of sensory mechanisms in the kidney. Clin Exp Hypertens A. 1987;9 (Suppl 1):1–13. doi: 10.3109/10641968709160160. [DOI] [PubMed] [Google Scholar]
  22. Needleman P., Marshall G. R., Johnson E. M., Jr Determinants and modification of adrenergic and vascular resistance in the kidney. Am J Physiol. 1974 Sep;227(3):665–669. doi: 10.1152/ajplegacy.1974.227.3.665. [DOI] [PubMed] [Google Scholar]
  23. Oken D. E., Arce M. L., Wilson D. R. Glycerol-induced hemoglobinuric acute renal failure in the rat. I. Micropuncture study of the development of oliguria. J Clin Invest. 1966 May;45(5):724–735. doi: 10.1172/JCI105387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Passon P. G., Peuler J. D. A simplified radiometric assay for plasma norepinephrine and epinephrine. Anal Biochem. 1973 Feb;51(2):618–631. doi: 10.1016/0003-2697(73)90517-4. [DOI] [PubMed] [Google Scholar]
  25. Reubi F. C., Vorburger C., Tuckman J. Renal distribution volumes of indocyanine green, ( 51 Cr)EDTA, and 24 Na in man during acute renal failure after shock. Implications for the pathogenesis of anuria. J Clin Invest. 1973 Feb;52(2):223–235. doi: 10.1172/JCI107179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. VanBenthuysen K. M., McMurtry I. F., Horwitz L. D. Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro. J Clin Invest. 1987 Jan;79(1):265–274. doi: 10.1172/JCI112793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Vertel R. M., Knochel J. P. Nonoliguric acute renal failure. JAMA. 1967 May 15;200(7):598–602. [PubMed] [Google Scholar]
  28. Wallenstein S., Zucker C. L., Fleiss J. L. Some statistical methods useful in circulation research. Circ Res. 1980 Jul;47(1):1–9. doi: 10.1161/01.res.47.1.1. [DOI] [PubMed] [Google Scholar]
  29. Zambraski E. J., Prosnitz E. H., DiBona G. F. Lack of evidence for neurogenic renal vasodilatation in anesthetized dogs. Proc Soc Exp Biol Med. 1978 Jul;158(3):462–465. doi: 10.3181/00379727-158-40226. [DOI] [PubMed] [Google Scholar]
  30. Zimmerman B. G. Actions of angiotensin on adrenergic nerve endings. Fed Proc. 1978 Feb;37(2):199–202. [PubMed] [Google Scholar]
  31. Zimmerman B. G., Gisslen J. Pattern of renal vasoconstriction and transmitter release during sympathetic stimulation in presence of angiotensin and cocaine. J Pharmacol Exp Ther. 1968 Oct;163(2):320–329. [PubMed] [Google Scholar]
  32. Zimmerman B. G., Whitmore L. Effect of angiotensin and phenoxybenzamine on release of norepinephrine in vessels during sympathetic nerve stimulation. Int J Neuropharmacol. 1967 Jan;6(1):27–38. doi: 10.1016/0028-3908(67)90039-1. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES