3,3,6,6-Tetra­methyl-9-phenyl-3,4,5,6-tetra­hydro-9H-xanthene-1,8(2H,7H)-dione

Abstract

In the title compound, C₂₃H₂₆O₃, the three six-membered rings of the xanthene system are non-planar, having total puckering amplitudes, Q _T, of 0.443 (2), 0.202 (2) and 0.449 (2) Å. The central ring adopts a boat conformation and the outer rings adopt sofa conformations. The crystal structure is stabilized by van der Waals inter­actions.

Related literature

For the biological and pharmaceutical properties of xanthenes, see: Hideo (1981 ▶); Lambert et al. (1997 ▶); Poupelin et al. (1978 ▶). For puckering parameters, see: Cremer & Pople (1975 ▶).

Experimental

Crystal data

• C₂₃H₂₆O₃

• M _r = 350.44

• Monoclinic,

• a = 6.0562 (5) Å

• b = 19.7680 (18) Å

• c = 16.4325 (13) Å

• β = 97.924 (3)°

• V = 1948.5 (3) ų

• Z = 4

• Mo Kα radiation

• μ = 0.08 mm⁻¹

• T = 293 K

• 0.17 × 0.15 × 0.11 mm

Data collection

• Bruker SMART APEX CCD diffractometer

• Absorption correction: multi-scan (SADABS; Bruker, 1998 ▶) T _min = 0.987, T _max = 0.992

• 11861 measured reflections

• 4284 independent reflections

• 2825 reflections with I > 2σ(I)

• R _int = 0.035

Refinement

• R[F ² > 2σ(F ²)] = 0.050

• wR(F ²) = 0.138

• S = 1.03

• 4284 reflections

• 239 parameters

• H-atom parameters constrained

• Δρ_max = 0.17 e Å⁻³

• Δρ_min = −0.20 e Å⁻³

Data collection: SMART (Bruker, 2001 ▶); cell refinement: SAINT (Bruker, 2001 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: PLATON (Spek, 2009 ▶); software used to prepare material for publication: SHELXL97.

Supplementary Material

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

supplementary crystallographic information

Comment

Xanthenes are an important class of organic compounds that received considerable attention from many pharmaceuticals and organic chemists, actually because of the broad spectrum of their biological and pharmaceutical properties such as agricultural bactericide effects (Hideo, 1981), photodynamic therapy, anti-inflammatory activities (Poupelin et al., 1978) and antiviral effects (Lambert et al., 1997). Considering the importance of the title compound (I), we report here the crystal structure of it.

In the molecule of (I), (Fig. 1), rings A(C14—C6), B(O1/C6/C5/C4/C3/C2) and C(C2—C7) are not planar, having total puckering amplitudes, Q_T, of 0.443 (2), 0.202 (2) and 0.449 (2) Å, respectively. They adopt envelope [Φ = 12.2 (3) and θ = 130.5 (2) °], boat [Φ = 351.8 (5) and θ = 102.5 (5) °] and envelope [Φ = 45.2 (4) and θ = 125.6 (2) °] conformations (Cremer & Pople, 1975). In rings A and C, atoms C13 and C8 are displaced by 0.609 (1) and 0.616 (1) Å from the plane of the other ring atoms, respectively. Ring D(C15—C20) is, of course, planar.

The crystal structure is stabilized by van der Waals interactions.

Experimental

A mixture of benzaldehyde (10 mmol), 5, 5-dimethyl-1,3-cyclohexanedione (2. 20 mmol) were mixed along with 20 ml of ethanol, to that ammonium acetate (10 mmol) was added and refluxed on waterbath for about 1 h. The progress of the reaction was monitored by TLC. After conforming that the reaction got completed, the reaction mixture was allowed to cool to room temperature and left aside for a day. Yellow colour solid crystals were started growing from the mother liquor. It was filtered and washed with diethyl ether to ensure pure crystals [yield: 91%, m.p. 478–480 K].

Refinement

The H atoms were placed in calculated positions and allowed to ride on their carrier atoms with C—H = 0.93–0.98 Å and with U_iso(H) = 1.2U_eq(C) for CH, CH₂ and U_iso(H) = 1.5U_eq(C) for CH₃ groups.

Figures

Fig. 1.

The molecular structure of the title compound, showing 30% probability displacement ellipsoids and the atom-numbering scheme.

Crystal data

C23H26O3	F(000) = 752
Mr = 350.44	Dx = 1.195 Mg m−3
Monoclinic, P21/c	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ybc	Cell parameters from 2500 reflections
a = 6.0562 (5) Å	θ = 2–27°
b = 19.7680 (18) Å	µ = 0.08 mm−1
c = 16.4325 (13) Å	T = 293 K
β = 97.924 (3)°	Needle, colourless
V = 1948.5 (3) Å3	0.17 × 0.15 × 0.11 mm
Z = 4

Data collection

Bruker SMART APEX CCD diffractometer	4284 independent reflections
Radiation source: fine-focus sealed tube	2825 reflections with I > 2σ(I)
graphite	Rint = 0.035
ω scans	θmax = 27.1°, θmin = 1.6°
Absorption correction: multi-scan (SADABS; Bruker, 1998)	h = −5→7
Tmin = 0.987, Tmax = 0.992	k = −25→25
11861 measured reflections	l = −21→12

Refinement

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.050	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.138	H-atom parameters constrained
S = 1.03	w = 1/[σ2(Fo2) + (0.0661P)2 + 0.1411P] where P = (Fo2 + 2Fc2)/3
4284 reflections	(Δ/σ)max < 0.001
239 parameters	Δρmax = 0.17 e Å−3
0 restraints	Δρmin = −0.20 e Å−3

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq
C2	0.2342 (3)	0.26716 (7)	0.39187 (9)	0.0364 (4)
C3	0.0380 (2)	0.27207 (7)	0.34340 (9)	0.0353 (3)
C4	−0.0306 (3)	0.22377 (7)	0.27309 (9)	0.0363 (4)
H4	−0.1866	0.2110	0.2741	0.044*
C5	0.1110 (3)	0.16067 (8)	0.28674 (9)	0.0379 (4)
C6	0.3004 (3)	0.15872 (7)	0.33973 (9)	0.0390 (4)
C7	0.3232 (3)	0.31533 (8)	0.45793 (9)	0.0424 (4)
H7A	0.4811	0.3220	0.4562	0.051*
H7B	0.3068	0.2956	0.5108	0.051*
C8	0.2064 (3)	0.38413 (8)	0.45065 (10)	0.0450 (4)
C9	−0.0457 (3)	0.37197 (10)	0.43150 (11)	0.0544 (5)
H9A	−0.0970	0.3516	0.4792	0.065*
H9B	−0.1199	0.4153	0.4221	0.065*
C10	−0.1139 (3)	0.32744 (9)	0.35821 (10)	0.0447 (4)
C11	0.0384 (3)	0.09875 (8)	0.24133 (10)	0.0479 (4)
C12	0.1983 (4)	0.03983 (9)	0.24839 (11)	0.0607 (5)
H12A	0.2987	0.0452	0.2077	0.073*
H12B	0.1141	−0.0014	0.2355	0.073*
C13	0.3369 (3)	0.03208 (8)	0.33293 (10)	0.0497 (4)
C14	0.4530 (3)	0.09951 (8)	0.35552 (11)	0.0504 (4)
H14A	0.5142	0.0988	0.4133	0.060*
H14B	0.5761	0.1048	0.3240	0.060*
C15	−0.0128 (3)	0.25771 (7)	0.19070 (9)	0.0360 (4)
C16	0.1833 (3)	0.28868 (9)	0.17640 (10)	0.0457 (4)
H16	0.3073	0.2874	0.2167	0.055*
C17	0.1970 (3)	0.32159 (9)	0.10281 (11)	0.0534 (5)
H17	0.3297	0.3421	0.0939	0.064*
C18	0.0143 (4)	0.32390 (9)	0.04283 (11)	0.0562 (5)
H18	0.0228	0.3465	−0.0063	0.067*
C19	−0.1807 (3)	0.29273 (10)	0.05584 (11)	0.0601 (5)
H19	−0.3039	0.2939	0.0153	0.072*
C20	−0.1939 (3)	0.25964 (9)	0.12930 (10)	0.0495 (4)
H20	−0.3261	0.2384	0.1375	0.059*
C21	0.2861 (3)	0.42570 (9)	0.38171 (13)	0.0613 (5)
H21A	0.2137	0.4690	0.3783	0.092*
H21B	0.2502	0.4022	0.3305	0.092*
H21C	0.4446	0.4319	0.3931	0.092*
C22	0.2621 (4)	0.42158 (12)	0.53235 (13)	0.0775 (7)
H22A	0.4210	0.4241	0.5467	0.116*
H22B	0.1990	0.3977	0.5745	0.116*
H22C	0.2012	0.4665	0.5271	0.116*
C23	0.5131 (4)	−0.02346 (10)	0.32996 (14)	0.0785 (7)
H23A	0.4405	−0.0654	0.3136	0.118*
H23B	0.5982	−0.0285	0.3834	0.118*
H23C	0.6106	−0.0111	0.2910	0.118*
C24	0.1837 (4)	0.01311 (11)	0.39644 (13)	0.0756 (6)
H24A	0.1096	−0.0288	0.3808	0.113*
H24B	0.0748	0.0481	0.3987	0.113*
H24C	0.2710	0.0082	0.4495	0.113*
O1	0.37769 (18)	0.21342 (5)	0.38742 (7)	0.0448 (3)
O2	−0.2918 (2)	0.33452 (7)	0.31414 (8)	0.0672 (4)
O3	−0.1434 (2)	0.09604 (6)	0.19873 (9)	0.0699 (4)

Atomic displacement parameters (Ų)

	U11	U22	U33	U12	U13	U23
C2	0.0412 (9)	0.0298 (8)	0.0381 (8)	0.0020 (7)	0.0052 (7)	0.0017 (6)
C3	0.0360 (8)	0.0329 (8)	0.0367 (8)	0.0003 (7)	0.0043 (6)	−0.0007 (6)
C4	0.0323 (8)	0.0352 (8)	0.0397 (8)	−0.0005 (7)	−0.0007 (6)	−0.0004 (6)
C5	0.0453 (9)	0.0316 (8)	0.0358 (8)	0.0009 (7)	0.0018 (7)	0.0005 (6)
C6	0.0431 (9)	0.0298 (8)	0.0428 (8)	0.0002 (7)	0.0018 (7)	−0.0019 (7)
C7	0.0490 (10)	0.0378 (9)	0.0388 (8)	−0.0017 (8)	−0.0003 (7)	−0.0023 (7)
C8	0.0460 (10)	0.0368 (9)	0.0524 (10)	0.0014 (8)	0.0074 (8)	−0.0094 (7)
C9	0.0492 (11)	0.0530 (11)	0.0636 (11)	0.0044 (9)	0.0172 (9)	−0.0163 (9)
C10	0.0398 (9)	0.0451 (10)	0.0501 (9)	0.0030 (8)	0.0096 (8)	−0.0026 (8)
C11	0.0638 (12)	0.0382 (9)	0.0386 (9)	−0.0004 (8)	−0.0042 (8)	−0.0007 (7)
C12	0.0880 (15)	0.0391 (10)	0.0497 (10)	0.0125 (10)	−0.0097 (10)	−0.0101 (8)
C13	0.0689 (12)	0.0319 (9)	0.0455 (9)	0.0069 (8)	−0.0020 (8)	−0.0009 (7)
C14	0.0518 (10)	0.0384 (9)	0.0579 (10)	0.0084 (8)	−0.0028 (8)	−0.0019 (8)
C15	0.0395 (8)	0.0305 (8)	0.0363 (8)	0.0027 (7)	−0.0006 (6)	−0.0030 (6)
C16	0.0452 (10)	0.0467 (10)	0.0440 (9)	−0.0038 (8)	0.0018 (7)	−0.0049 (8)
C17	0.0653 (12)	0.0435 (10)	0.0540 (10)	−0.0106 (9)	0.0178 (9)	−0.0038 (8)
C18	0.0869 (15)	0.0412 (10)	0.0406 (9)	0.0031 (10)	0.0093 (9)	0.0046 (8)
C19	0.0665 (13)	0.0629 (12)	0.0457 (10)	0.0049 (11)	−0.0113 (9)	0.0072 (9)
C20	0.0447 (10)	0.0511 (11)	0.0491 (10)	−0.0035 (8)	−0.0065 (8)	0.0037 (8)
C21	0.0562 (12)	0.0397 (10)	0.0881 (14)	0.0017 (9)	0.0101 (10)	0.0126 (10)
C22	0.0799 (16)	0.0678 (14)	0.0827 (15)	0.0012 (12)	0.0036 (12)	−0.0377 (12)
C23	0.1014 (17)	0.0442 (11)	0.0823 (15)	0.0268 (12)	−0.0138 (13)	−0.0109 (10)
C24	0.0986 (17)	0.0577 (13)	0.0692 (13)	−0.0073 (12)	0.0070 (12)	0.0173 (10)
O1	0.0426 (6)	0.0322 (6)	0.0551 (7)	0.0053 (5)	−0.0092 (5)	−0.0062 (5)
O2	0.0462 (8)	0.0734 (10)	0.0784 (9)	0.0206 (7)	−0.0042 (7)	−0.0149 (7)
O3	0.0744 (10)	0.0486 (8)	0.0766 (9)	−0.0028 (7)	−0.0251 (8)	−0.0129 (7)

Geometric parameters (Å, °)

C2—C3	1.340 (2)	C13—C24	1.536 (3)
C2—O1	1.3809 (17)	C13—C23	1.536 (3)
C2—C7	1.488 (2)	C14—H14A	0.9700
C3—C10	1.471 (2)	C14—H14B	0.9700
C3—C4	1.512 (2)	C15—C20	1.384 (2)
C4—C5	1.513 (2)	C15—C16	1.385 (2)
C4—C15	1.528 (2)	C16—C17	1.386 (2)
C4—H4	0.9800	C16—H16	0.9300
C5—C6	1.341 (2)	C17—C18	1.377 (3)
C5—C11	1.469 (2)	C17—H17	0.9300
C6—O1	1.3788 (18)	C18—C19	1.375 (3)
C6—C14	1.492 (2)	C18—H18	0.9300
C7—C8	1.530 (2)	C19—C20	1.385 (2)
C7—H7A	0.9700	C19—H19	0.9300
C7—H7B	0.9700	C20—H20	0.9300
C8—C22	1.529 (2)	C21—H21A	0.9600
C8—C21	1.531 (2)	C21—H21B	0.9600
C8—C9	1.534 (2)	C21—H21C	0.9600
C9—C10	1.503 (2)	C22—H22A	0.9600
C9—H9A	0.9700	C22—H22B	0.9600
C9—H9B	0.9700	C22—H22C	0.9600
C10—O2	1.221 (2)	C23—H23A	0.9600
C11—O3	1.222 (2)	C23—H23B	0.9600
C11—C12	1.509 (2)	C23—H23C	0.9600
C12—C13	1.529 (2)	C24—H24A	0.9600
C12—H12A	0.9700	C24—H24B	0.9600
C12—H12B	0.9700	C24—H24C	0.9600
C13—C14	1.529 (2)
C3—C2—O1	122.50 (13)	C14—C13—C23	109.43 (16)
C3—C2—C7	126.13 (14)	C24—C13—C23	109.54 (17)
O1—C2—C7	111.33 (13)	C6—C14—C13	112.88 (14)
C2—C3—C10	118.61 (14)	C6—C14—H14A	109.0
C2—C3—C4	122.44 (13)	C13—C14—H14A	109.0
C10—C3—C4	118.94 (13)	C6—C14—H14B	109.0
C3—C4—C5	108.46 (12)	C13—C14—H14B	109.0
C3—C4—C15	110.74 (12)	H14A—C14—H14B	107.8
C5—C4—C15	112.66 (12)	C20—C15—C16	118.41 (14)
C3—C4—H4	108.3	C20—C15—C4	120.80 (14)
C5—C4—H4	108.3	C16—C15—C4	120.77 (13)
C15—C4—H4	108.3	C15—C16—C17	120.76 (16)
C6—C5—C11	118.38 (14)	C15—C16—H16	119.6
C6—C5—C4	122.44 (13)	C17—C16—H16	119.6
C11—C5—C4	119.17 (14)	C18—C17—C16	120.09 (17)
C5—C6—O1	122.64 (13)	C18—C17—H17	120.0
C5—C6—C14	126.09 (14)	C16—C17—H17	120.0
O1—C6—C14	111.27 (13)	C19—C18—C17	119.77 (16)
C2—C7—C8	113.26 (13)	C19—C18—H18	120.1
C2—C7—H7A	108.9	C17—C18—H18	120.1
C8—C7—H7A	108.9	C18—C19—C20	120.08 (17)
C2—C7—H7B	108.9	C18—C19—H19	120.0
C8—C7—H7B	108.9	C20—C19—H19	120.0
H7A—C7—H7B	107.7	C15—C20—C19	120.88 (17)
C22—C8—C7	108.54 (15)	C15—C20—H20	119.6
C22—C8—C21	109.63 (16)	C19—C20—H20	119.6
C7—C8—C21	110.20 (14)	C8—C21—H21A	109.5
C22—C8—C9	110.41 (15)	C8—C21—H21B	109.5
C7—C8—C9	108.23 (14)	H21A—C21—H21B	109.5
C21—C8—C9	109.80 (15)	C8—C21—H21C	109.5
C10—C9—C8	114.33 (14)	H21A—C21—H21C	109.5
C10—C9—H9A	108.7	H21B—C21—H21C	109.5
C8—C9—H9A	108.7	C8—C22—H22A	109.5
C10—C9—H9B	108.7	C8—C22—H22B	109.5
C8—C9—H9B	108.7	H22A—C22—H22B	109.5
H9A—C9—H9B	107.6	C8—C22—H22C	109.5
O2—C10—C3	120.52 (15)	H22A—C22—H22C	109.5
O2—C10—C9	122.07 (15)	H22B—C22—H22C	109.5
C3—C10—C9	117.34 (15)	C13—C23—H23A	109.5
O3—C11—C5	120.72 (16)	C13—C23—H23B	109.5
O3—C11—C12	121.90 (15)	H23A—C23—H23B	109.5
C5—C11—C12	117.37 (15)	C13—C23—H23C	109.5
C11—C12—C13	114.43 (14)	H23A—C23—H23C	109.5
C11—C12—H12A	108.7	H23B—C23—H23C	109.5
C13—C12—H12A	108.7	C13—C24—H24A	109.5
C11—C12—H12B	108.7	C13—C24—H24B	109.5
C13—C12—H12B	108.7	H24A—C24—H24B	109.5
H12A—C12—H12B	107.6	C13—C24—H24C	109.5
C12—C13—C14	108.04 (14)	H24A—C24—H24C	109.5
C12—C13—C24	109.55 (17)	H24B—C24—H24C	109.5
C14—C13—C24	110.41 (15)	C6—O1—C2	117.81 (11)
C12—C13—C23	109.85 (14)
O1—C2—C3—C10	173.83 (13)	C6—C5—C11—O3	172.63 (16)
C7—C2—C3—C10	−3.8 (2)	C4—C5—C11—O3	−6.6 (2)
O1—C2—C3—C4	−7.5 (2)	C6—C5—C11—C12	−8.5 (2)
C7—C2—C3—C4	174.82 (14)	C4—C5—C11—C12	172.31 (15)
C2—C3—C4—C5	19.19 (19)	O3—C11—C12—C13	−145.42 (19)
C10—C3—C4—C5	−162.15 (13)	C5—C11—C12—C13	35.7 (2)
C2—C3—C4—C15	−104.92 (16)	C11—C12—C13—C14	−53.6 (2)
C10—C3—C4—C15	73.74 (17)	C11—C12—C13—C24	66.7 (2)
C3—C4—C5—C6	−16.4 (2)	C11—C12—C13—C23	−172.93 (18)
C15—C4—C5—C6	106.60 (16)	C5—C6—C14—C13	−23.1 (2)
C3—C4—C5—C11	162.83 (13)	O1—C6—C14—C13	156.85 (14)
C15—C4—C5—C11	−74.21 (18)	C12—C13—C14—C6	46.2 (2)
C11—C5—C6—O1	−177.46 (14)	C24—C13—C14—C6	−73.61 (19)
C4—C5—C6—O1	1.7 (2)	C23—C13—C14—C6	165.75 (16)
C11—C5—C6—C14	2.4 (2)	C3—C4—C15—C20	−125.34 (15)
C4—C5—C6—C14	−178.36 (15)	C5—C4—C15—C20	112.98 (16)
C3—C2—C7—C8	−17.9 (2)	C3—C4—C15—C16	53.10 (19)
O1—C2—C7—C8	164.25 (13)	C5—C4—C15—C16	−68.58 (18)
C2—C7—C8—C22	164.25 (16)	C20—C15—C16—C17	0.9 (2)
C2—C7—C8—C21	−75.68 (18)	C4—C15—C16—C17	−177.63 (15)
C2—C7—C8—C9	44.40 (18)	C15—C16—C17—C18	0.1 (3)
C22—C8—C9—C10	−172.24 (16)	C16—C17—C18—C19	−0.8 (3)
C7—C8—C9—C10	−53.6 (2)	C17—C18—C19—C20	0.6 (3)
C21—C8—C9—C10	66.8 (2)	C16—C15—C20—C19	−1.1 (2)
C2—C3—C10—O2	178.27 (16)	C4—C15—C20—C19	177.38 (16)
C4—C3—C10—O2	−0.4 (2)	C18—C19—C20—C15	0.4 (3)
C2—C3—C10—C9	−4.7 (2)	C5—C6—O1—C2	12.5 (2)
C4—C3—C10—C9	176.63 (14)	C14—C6—O1—C2	−167.45 (13)
C8—C9—C10—O2	−148.28 (17)	C3—C2—O1—C6	−9.5 (2)
C8—C9—C10—C3	34.7 (2)	C7—C2—O1—C6	168.44 (13)