2-(Prop-2-en­yl)-1,2-benzisothia­zol-3(2H)-one 1,1-dioxide

Abstract

In the title compound, C₁₀H₉NO₃S, the benzisothia­zole group is almost planar (with a maximum deviation of 1.61 Å). The crystal structure is stabilized by weak inter­molecular C—H⋯O hydrogen bonds, forming a chain of mol­ecules along b.

Related literature

For the synthesis of benzothia­zine and benzisothia­zol deriv­atives, see: Zia-ur-Rehman, Anwar & Ahmad (2006 ▶); Zia-ur-Rehman, Anwar, Ahmad & Siddiqui (2006 ▶); Siddiqui et al. (2007 ▶) Zia-ur-Rehman et al. (2009 ▶). For the biological activity of benzisothia­zols, see: Kapui et al. (2003 ▶); Liang et al. (2006 ▶). For related structures, see: Siddiqui, Ahmad, Siddiqui et al. (2007a ▶,b ▶,c ▶).

Experimental

Crystal data

• C₁₀H₉NO₃S

• M _r = 223.24

• Triclinic,

• a = 7.2169 (8) Å

• b = 7.8347 (7) Å

• c = 10.3849 (12) Å

• α = 105.530 (3)°

• β = 91.586 (3)°

• γ = 112.047 (3)°

• V = 518.95 (10) ų

• Z = 2

• Mo Kα radiation

• μ = 0.30 mm⁻¹

• T = 296 K

• 0.37 × 0.26 × 0.18 mm

Data collection

• Bruker APEXII CCD area-detector diffractometer

• Absorption correction: none

• 5460 measured reflections

• 2342 independent reflections

• 1728 reflections with I > 2σ(I)

• R _int = 0.022

Refinement

• R[F ² > 2σ(F ²)] = 0.041

• wR(F ²) = 0.118

• S = 1.06

• 2342 reflections

• 136 parameters

• H-atom parameters constrained

• Δρ_max = 0.26 e Å⁻³

• Δρ_min = −0.26 e Å⁻³

Data collection: APEX2 (Bruker, 2007 ▶); cell refinement: SAINT (Bruker, 2007 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: PLATON (Spek, 2009 ▶) and Mercury (Macrae et al., 2006 ▶); software used to prepare material for publication: PLATON.

Supplementary Material

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

Table 1. Hydrogen-bond geometry (Å, °).

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
C6—H6⋯O1i	0.93	2.36	3.216 (3)	153

Symmetry code: (i) .

supplementary crystallographic information

Comment

Besides being used as a sweetener, saccharin and its various derivatives are well known for their different type of biological activities e.g., it has been identified as an important molecular component in various classes of 5-HTla antagonists, analgesics and human mast cell tryptase inhibitors (Kapui et al., 2003; Liang et al., 2006). N-alkyl derivatives of saccharin have been successfully transformed to non-steroidal anti-inflammatory drugs e.g., piroxicam and meloxicam.

As part of a research program synthesizing various bioactive benzothiazines (Zia-ur-Rehman et al., 2009; Siddiqui et al., 2007), we have in addition, worked on the synthesis of benzisothiazole derivatives. We herein report the crystal structure of the title compound (Scheme and figure 1). The benzisothiazole moiety is exactly planar. The molecular dimensions are in accord with the corresponding dimensions reported in similar structures (Siddiqui, Ahmad, Siddiqui et al., 2007a; Siddiqui, Ahmad, Siddiqui et al., 2007b; Siddiqui, Ahmad, Siddiqui et al., 2007c). Each molecule is linked to its adjacent one through C—H···O contacts forming a chain of molecules along b (Figure 2).

Experimental

A mixture of 2,3-dihydro-1,2-benzisothiazol-3-one-1,1-dioxide (1.83 g, 10.0 mmoles), dimethyl formamide (5.0 ml) and allyl bromide (1.20 g, 10.0 mmoles) was stirred for a period of one hour at 90°C. Contents were cooled to room temperature; poured over crushed ice to get white coloured precipitates which were filtered, washed and dried. Crystallization of the white precipitate in methanol afforded suitable crystals for X-ray studies.

Refinement

H atoms were placed in geometric positions (C—H distance = 0.93 to 0.96 Å) using a riding model with U_iso(H) = 1.2 U_eq(C).

Figures

Fig. 1.

The molecular structure of the title compound with displacement ellipsoids at the 50% probability level.

Fig. 2.

Perspective view of the crystal packing showing hydrogen-bonded interactions (dashed lines). H atoms not involved in hydrogen bonding have been omitted for clarity.

Crystal data

C10H9NO3S	Z = 2
Mr = 223.24	F(000) = 232
Triclinic, P1	Dx = 1.429 Mg m−3
Hall symbol: -P 1	Mo Kα radiation, λ = 0.71073 Å
a = 7.2169 (8) Å	Cell parameters from 2362 reflections
b = 7.8347 (7) Å	θ = 3.1–27.3°
c = 10.3849 (12) Å	µ = 0.30 mm−1
α = 105.530 (3)°	T = 296 K
β = 91.586 (3)°	Needles, colourless
γ = 112.047 (3)°	0.37 × 0.26 × 0.18 mm
V = 518.95 (10) Å3

Data collection

Bruker APEXII CCD area-detector diffractometer	1728 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tube	Rint = 0.022
graphite	θmax = 27.5°, θmin = 2.9°
φ and ω scans	h = −9→9
5460 measured reflections	k = −10→6
2342 independent reflections	l = −11→13

Refinement

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.041	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.118	H-atom parameters constrained
S = 1.06	w = 1/[σ2(Fo2) + (0.0542P)2 + 0.1101P] where P = (Fo2 + 2Fc2)/3
2342 reflections	(Δ/σ)max < 0.001
136 parameters	Δρmax = 0.26 e Å−3
0 restraints	Δρmin = −0.26 e Å−3

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq
S1	0.39784 (8)	0.35030 (7)	0.26041 (5)	0.0536 (2)
O1	0.2640 (2)	0.6659 (2)	0.09710 (17)	0.0646 (4)
O2	0.6073 (2)	0.3953 (2)	0.29080 (18)	0.0759 (5)
O3	0.2677 (3)	0.2648 (2)	0.34679 (16)	0.0726 (5)
N1	0.3652 (3)	0.5452 (2)	0.25013 (17)	0.0515 (4)
C1	0.3079 (3)	0.2289 (3)	0.0897 (2)	0.0450 (4)
C2	0.2602 (3)	0.3453 (3)	0.0270 (2)	0.0431 (4)
C3	0.1889 (3)	0.2789 (3)	−0.1090 (2)	0.0533 (5)
H3	0.1557	0.3555	−0.1521	0.064*
C4	0.1684 (3)	0.0951 (3)	−0.1791 (2)	0.0635 (6)
H4	0.1223	0.0479	−0.2713	0.076*
C5	0.2147 (3)	−0.0205 (3)	−0.1155 (3)	0.0645 (6)
H5	0.1983	−0.1442	−0.1656	0.077*
C6	0.2844 (3)	0.0433 (3)	0.0204 (2)	0.0572 (6)
H6	0.3145	−0.0347	0.0636	0.069*
C7	0.2931 (3)	0.5357 (3)	0.1224 (2)	0.0463 (5)
C8	0.4052 (4)	0.7114 (3)	0.3697 (2)	0.0642 (6)
H8A	0.4591	0.8293	0.3443	0.077*
H8B	0.5060	0.7163	0.4359	0.077*
C9	0.2176 (5)	0.6993 (4)	0.4312 (3)	0.0823 (8)
H9	0.1606	0.5989	0.4683	0.099*
C10	0.1299 (5)	0.8116 (5)	0.4373 (3)	0.0945 (9)
H10A	0.1814	0.9141	0.4015	0.113*
H10B	0.0134	0.7926	0.4777	0.113*

Atomic displacement parameters (Ų)

	U11	U22	U33	U12	U13	U23
S1	0.0584 (3)	0.0538 (3)	0.0598 (4)	0.0253 (2)	0.0088 (2)	0.0306 (3)
O1	0.0772 (10)	0.0506 (8)	0.0818 (11)	0.0342 (7)	0.0108 (8)	0.0319 (8)
O2	0.0616 (10)	0.0850 (11)	0.0897 (12)	0.0328 (8)	−0.0054 (9)	0.0362 (10)
O3	0.0904 (12)	0.0726 (10)	0.0647 (10)	0.0278 (9)	0.0214 (9)	0.0418 (9)
N1	0.0612 (10)	0.0455 (9)	0.0537 (10)	0.0248 (8)	0.0095 (8)	0.0187 (8)
C1	0.0420 (10)	0.0435 (9)	0.0588 (12)	0.0201 (8)	0.0149 (9)	0.0249 (9)
C2	0.0391 (10)	0.0428 (9)	0.0554 (11)	0.0178 (8)	0.0139 (8)	0.0243 (9)
C3	0.0468 (11)	0.0607 (12)	0.0572 (13)	0.0207 (9)	0.0085 (9)	0.0262 (10)
C4	0.0540 (13)	0.0652 (14)	0.0616 (14)	0.0180 (11)	0.0098 (11)	0.0117 (11)
C5	0.0568 (13)	0.0470 (12)	0.0819 (17)	0.0195 (10)	0.0182 (12)	0.0080 (11)
C6	0.0514 (12)	0.0468 (11)	0.0845 (17)	0.0249 (9)	0.0194 (11)	0.0285 (11)
C7	0.0452 (10)	0.0429 (10)	0.0600 (12)	0.0198 (8)	0.0134 (9)	0.0259 (9)
C8	0.0702 (15)	0.0559 (12)	0.0604 (14)	0.0234 (11)	0.0031 (11)	0.0108 (11)
C9	0.111 (2)	0.0722 (16)	0.0749 (18)	0.0451 (16)	0.0323 (16)	0.0258 (14)
C10	0.109 (2)	0.098 (2)	0.0787 (19)	0.0495 (19)	0.0176 (17)	0.0177 (17)

Geometric parameters (Å, °)

S1—O2	1.4220 (16)	C4—C5	1.379 (3)
S1—O3	1.4253 (15)	C4—H4	0.9300
S1—N1	1.6596 (16)	C5—C6	1.374 (3)
S1—C1	1.743 (2)	C5—H5	0.9300
O1—C7	1.206 (2)	C6—H6	0.9300
N1—C7	1.385 (3)	C8—C9	1.495 (3)
N1—C8	1.467 (3)	C8—H8A	0.9700
C1—C6	1.382 (3)	C8—H8B	0.9700
C1—C2	1.384 (2)	C9—C10	1.253 (4)
C2—C3	1.376 (3)	C9—H9	0.9300
C2—C7	1.481 (3)	C10—H10A	0.9300
C3—C4	1.378 (3)	C10—H10B	0.9300
C3—H3	0.9300
O2—S1—O3	117.16 (10)	C6—C5—C4	121.4 (2)
O2—S1—N1	109.80 (9)	C6—C5—H5	119.3
O3—S1—N1	109.80 (9)	C4—C5—H5	119.3
O2—S1—C1	111.86 (10)	C5—C6—C1	116.9 (2)
O3—S1—C1	112.76 (9)	C5—C6—H6	121.5
N1—S1—C1	92.73 (8)	C1—C6—H6	121.5
C7—N1—C8	123.33 (17)	O1—C7—N1	123.46 (19)
C7—N1—S1	115.04 (13)	O1—C7—C2	127.23 (19)
C8—N1—S1	121.60 (14)	N1—C7—C2	109.31 (15)
C6—C1—C2	122.1 (2)	N1—C8—C9	111.41 (19)
C6—C1—S1	127.33 (16)	N1—C8—H8A	109.3
C2—C1—S1	110.60 (14)	C9—C8—H8A	109.3
C3—C2—C1	120.34 (18)	N1—C8—H8B	109.3
C3—C2—C7	127.38 (17)	C9—C8—H8B	109.3
C1—C2—C7	112.27 (17)	H8A—C8—H8B	108.0
C2—C3—C4	117.8 (2)	C10—C9—C8	126.1 (3)
C2—C3—H3	121.1	C10—C9—H9	116.9
C4—C3—H3	121.1	C8—C9—H9	116.9
C3—C4—C5	121.5 (2)	C9—C10—H10A	120.0
C3—C4—H4	119.3	C9—C10—H10B	120.0
C5—C4—H4	119.3	H10A—C10—H10B	120.0
O2—S1—N1—C7	112.66 (16)	C7—C2—C3—C4	−179.51 (17)
O3—S1—N1—C7	−117.16 (15)	C2—C3—C4—C5	0.9 (3)
C1—S1—N1—C7	−1.76 (15)	C3—C4—C5—C6	−0.4 (3)
O2—S1—N1—C8	−69.00 (18)	C4—C5—C6—C1	−0.6 (3)
O3—S1—N1—C8	61.18 (18)	C2—C1—C6—C5	1.2 (3)
C1—S1—N1—C8	176.58 (16)	S1—C1—C6—C5	−178.53 (15)
O2—S1—C1—C6	69.07 (19)	C8—N1—C7—O1	2.9 (3)
O3—S1—C1—C6	−65.5 (2)	S1—N1—C7—O1	−178.81 (15)
N1—S1—C1—C6	−178.31 (17)	C8—N1—C7—C2	−177.24 (16)
O2—S1—C1—C2	−110.65 (14)	S1—N1—C7—C2	1.1 (2)
O3—S1—C1—C2	114.77 (14)	C3—C2—C7—O1	−0.5 (3)
N1—S1—C1—C2	1.96 (14)	C1—C2—C7—O1	−179.66 (19)
C6—C1—C2—C3	−0.7 (3)	C3—C2—C7—N1	179.65 (18)
S1—C1—C2—C3	179.07 (14)	C1—C2—C7—N1	0.5 (2)
C6—C1—C2—C7	178.58 (16)	C7—N1—C8—C9	84.2 (3)
S1—C1—C2—C7	−1.68 (19)	S1—N1—C8—C9	−94.0 (2)
C1—C2—C3—C4	−0.4 (3)	N1—C8—C9—C10	−114.2 (3)

Hydrogen-bond geometry (Å, °)

D—H···A	D—H	H···A	D···A	D—H···A
C6—H6···O1i	0.93	2.36	3.216 (3)	153

Symmetry codes: (i) x, y−1, z.