Abstract
Glucose titration studies were performed on 17 patients with either chronic pyelonephritis or chronic glomerulonephritis. Glomerular filtration rates for the group ranged from 4.3 to 58.1 ml per minute. In none of the patients in whom the glomerular filtration rate was over 15 ml per minute was there appreciable splay, and the mean titration curve for these patients resembled that obtained by Smith and associates in normal man (1). In half of this group of eight patients, GFR ranged from 16.6 to 22.7 ml per minute; in the other half values ranged from 42.3 to 58.1 ml per minute. Yet, the mean titration curves were identical for the two groups. In addition, no difference was observed in the titration curves for patients with pyelonephritis and those with glomerulonephritis. In patients with GFR values below 15 ml per minute, increased splay was observed, and below a GFR of 10 ml per minute, the splay was very marked. Both the absence of exaggerated splay in patients with reduction of glomerular filtration rate by as much as 85%, and the emergence of exaggerated splay in patients with more marked reduction of GFR, require explanation. Theoretical considerations are presented in the text.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BRICKER N. S., KLAHR S., RIESELBACH R. E. THE FUNCTIONAL ADAPTATION OF THE DISEASED KIDNEY. I. GLOMERULAR FILTRATION RATE. J Clin Invest. 1964 Oct;43:1915–1921. doi: 10.1172/JCI105065. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Beaven M. A., Maickel R. P. Stereoselectivity of norepinephrine storage sites in heart. Biochem Biophys Res Commun. 1964;14:509–513. doi: 10.1016/0006-291x(64)90260-8. [DOI] [PubMed] [Google Scholar]
- LETTERI J. M., WESSON L. G., Jr GLUCOSE TITRATION CURVES AS AN ESTIMATE OF INTRARENAL DISTRIBUTION OF GLOMERULAR FILTRATE IN PATIENTS WITH CONGESTIVE HEART FAILURE. J Lab Clin Med. 1965 Mar;65:387–405. [PubMed] [Google Scholar]
- Shankel S. W., Robson A. M., Bricker N. S. On the mechanism of the splay in the glucose titration curve in advanced experimental renal disease in the rat. J Clin Invest. 1967 Feb;46(2):164–172. doi: 10.1172/JCI105519. [DOI] [PMC free article] [PubMed] [Google Scholar]