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. 1967 Mar;46(3):400–408. doi: 10.1172/JCI105541

Studies of Cryoproteins in Systemic Lupus Erythematosus*

Lonnie B Hanauer 1,†, Charles L Christian 1,‡
PMCID: PMC297060  PMID: 4164677

Abstract

Cryoproteins observed in patients with systemic lupus erythematosus were shown to be of “mixed type,” consisting largely of IgG and IgM. The IgM moiety possessed anti-IgG globulin reactivity and precipitated in the cold after mixing with a source of IgG. The IgM fraction of one cryoprotein precipitated only with the same patient's IgG. Antisera prepared against purified cryoproteins regularly recognized IgM, IgG, the 11 S component of C′, and α2-macroglobulin. C′4 (β1E) and C′3 (β1C) were recognized by four and two antisera, respectively. Antisera prepared against two cryoproteins reacted (after absorption) only with the sera of origin. These “unique” antigens were associated with IgM, were destroyed by mercaptoethanol treatment, and, in one patient, were shown to disappear subsequent to clinical improvement.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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