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. 1996 Jan-Mar;38(1):38–42.

ERYTHROCYTE ALDEHYDE DEHYDROGENASE = A POTENTIAL MARKER FOR ALCOHOL DEPENDENCE

Pratitma Murthy *,*, SC Guru **, SM Channabasavanna *, DK Subbakrishna **, Taranath Shetty **
PMCID: PMC2970779  PMID: 21584116

Abstract

The present study explored the utility of erythrocyte aldehyde dehydrogenase (ALDH) as a peripheral marker in alcoholism. The ALDH levels in aocoholics, their first degree nonalcholic relative and controls were compared. ALDH was found to be significantly lower in alcoholics (3.38±1.70 mU p< 0.001) and their first degree relatives (4.04±1.55 mU p< 0.05) compared to controls (5.06±1 55mU). Low ALDH levels among alcoholics persisted despite abstinence. The levels did not correlate with indices of hepatic dysfunction or with severity of alcoholism. These findings indicate that low erythrocyte ALDH may be considered as a biochemical trait marker associated with alcoholics, and the alcohol abuse would further decrease enzyme activitiy. To evaluate this proposition, logitudinal studies involving high risk progeny of alcohol dependents is being planned.

Keywords: Aldehyde deydrogenase, Familial Alcoholism, Alcohol Dependence

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Selected References

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  1. Agarwal D. P., Tobar-Rojas L., Harada S., Goedde H. W. Comparative study of erythrocyte aldehyde dehydrogenase in alcoholics and control subjects. Pharmacol Biochem Behav. 1983;18 (Suppl 1):89–95. doi: 10.1016/0091-3057(83)90152-1. [DOI] [PubMed] [Google Scholar]
  2. Asaad M. M., Clarke D. E. Studies on the biochemical aspects of the 'disulfiram-like' reaction induced by oral hypoglycemics. Eur J Pharmacol. 1976 Feb;35(2):301–307. doi: 10.1016/0014-2999(76)90232-6. [DOI] [PubMed] [Google Scholar]
  3. Ballenger J. C., Goodwin F. K., Major L. F., Brown G. L. Alcohol and central serotonin metabolism in man. Arch Gen Psychiatry. 1979 Feb;36(2):224–227. doi: 10.1001/archpsyc.1979.01780020114013. [DOI] [PubMed] [Google Scholar]
  4. Begleiter H., Porjesz B. Potential biological markers in individuals at high risk for developing alcoholism. Alcohol Clin Exp Res. 1988 Aug;12(4):488–493. doi: 10.1111/j.1530-0277.1988.tb00231.x. [DOI] [PubMed] [Google Scholar]
  5. Guru S. C., Shetty K. T. Methodological aspects of aldehyde dehydrogenase assay by spectrophotometric technique. Alcohol. 1990 Sep-Oct;7(5):397–401. doi: 10.1016/0741-8329(90)90022-5. [DOI] [PubMed] [Google Scholar]
  6. Harada S., Agarwal D. P., Goedde H. W. Aldehyde dehydrogenase polymorphism and alcohol metabolism in alcoholics. Alcohol. 1985 May-Jun;2(3):391–392. doi: 10.1016/0741-8329(85)90100-4. [DOI] [PubMed] [Google Scholar]
  7. Jenkins W. J., Cakebread K., Palmer K. R. Effect of alcohol consumption on hepatic aldehyde dehydrogenase activity in alcoholic patients. Lancet. 1984 May 12;1(8385):1048–1049. doi: 10.1016/s0140-6736(84)91453-3. [DOI] [PubMed] [Google Scholar]
  8. Kitson T. M. The effect of 5,5'-dithiobis(1-methyltetrazole) on cytoplasmic aldehyde dehydrogenase and its implications for cephalosporin-alcohol reactions. Alcohol Clin Exp Res. 1986 Jan-Feb;10(1):27–32. doi: 10.1111/j.1530-0277.1986.tb05608.x. [DOI] [PubMed] [Google Scholar]
  9. Lin C. C., Potter J. J., Mezey E. Erythrocyte aldehyde dehydrogenase activity in alcoholism. Alcohol Clin Exp Res. 1984 Nov-Dec;8(6):539–541. doi: 10.1111/j.1530-0277.1984.tb05725.x. [DOI] [PubMed] [Google Scholar]
  10. Matthewson K., Record C. O. Erythrocyte aldehyde dehydrogenase activity in alcoholic subjects and its value as a marker for hepatic aldehyde dehydrogenase in subjects with and without liver disease. Clin Sci (Lond) 1986 Mar;70(3):295–299. doi: 10.1042/cs0700295. [DOI] [PubMed] [Google Scholar]
  11. Murthy P., Guru S. C., Shetty K. T., Ray R., Channabasavanna S. M. Diazepam- and chlordiazepoxide-mediated increases in erythrocyte aldehyde dehydrogenase activity and its possible implications. Alcohol. 1992 May-Jun;9(3):199–202. doi: 10.1016/0741-8329(92)90053-d. [DOI] [PubMed] [Google Scholar]
  12. Sedmak J. J., Grossberg S. E. A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. Anal Biochem. 1977 May 1;79(1-2):544–552. doi: 10.1016/0003-2697(77)90428-6. [DOI] [PubMed] [Google Scholar]
  13. Sherlock S. Alcohol-related liver disease: clinical aspects and management. Br Med Bull. 1982 Jan;38(1):67–70. doi: 10.1093/oxfordjournals.bmb.a071736. [DOI] [PubMed] [Google Scholar]
  14. Thomas M., Halsall S., Peters T. J. Role of hepatic acetaldehyde dehydrogenase in alcoholism: demonstration of persistent reduction of cytosolic activity in abstaining patients. Lancet. 1982 Nov 13;2(8307):1057–1058. doi: 10.1016/s0140-6736(82)90001-0. [DOI] [PubMed] [Google Scholar]
  15. Towell J. F., 3rd, Barboriak J. J., Townsend W. F., Kalbfleisch J. H., Wang R. I. Erythrocyte aldehyde dehydrogenase: assay of a potential biochemical marker of alcohol abuse. Clin Chem. 1986 May;32(5):734–738. [PubMed] [Google Scholar]
  16. Towell J., Garthwaite T., Wang R. Erythrocyte aldehyde dehydrogenase and disulfiram-like side effects of hypoglycemics and antianginals. Alcohol Clin Exp Res. 1985 Sep-Oct;9(5):438–442. doi: 10.1111/j.1530-0277.1985.tb05579.x. [DOI] [PubMed] [Google Scholar]

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