Abstract
Immunoreactive insulin, like inulin, quickly equilibrates with interstitial fluid, as evidenced by recovery in thoracic duct lymph in man. Insulin-like activity not accounted for by immunoreactive insulin behaves as a large protein and is confined to the vascular compartment.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ANTONIADES H. N., BOUGAS J. A., CAMERINI-DAVALOS R., PYLE H. M. INSULIN REGULATORY MECHANISMS AND DIABETES MELLITUS. Diabetes. 1964 May-Jun;13:230–240. [PubMed] [Google Scholar]
- ANTONIADES H. N., HUBER A. M., BOSHELL B. R., SARAVIS C. A., GERSHOFF S. N. STUDIES ON THE STATE OF INSULIN IN BLOOD: PROPERTIES OF CIRCULATING "FREE" AND "BOUND" INSULIN. Endocrinology. 1965 Apr;76:709–721. doi: 10.1210/endo-76-4-709. [DOI] [PubMed] [Google Scholar]
- Berson S. A., Yalow R. S. Insulin in blood and insulin antibodies. Am J Med. 1966 May;40(5):676–690. doi: 10.1016/0002-9343(66)90148-3. [DOI] [PubMed] [Google Scholar]
- Bürgi H., Müller W. A., Humbel R. E., Labhart A., Froesch E. R. Non-suppressible insulin-like activity of human serum. I. Physicochemical properties, extraction and partial purification. Biochim Biophys Acta. 1966 Jun 29;121(2):349–359. doi: 10.1016/0304-4165(66)90124-3. [DOI] [PubMed] [Google Scholar]
- CERASI E., LUFT R. INSULIN RESPONSE TO GLUCOSE LOADING IN ACROMEGALY. Lancet. 1964 Oct 10;2(7363):769–771. doi: 10.1016/s0140-6736(64)90556-2. [DOI] [PubMed] [Google Scholar]
- CONSTABLE B. J. Estimation of Evans blue dye in blood plasma and its application to blood volume determination. Clin Sci. 1958 Nov;17(4):597–602. [PubMed] [Google Scholar]
- DANIEL P. M., GALE M. M., PRATT O. E. THE CONCENTRATION OF RADIOACTIVE IODINE IN THE THYROID LYMPH, THYROID VENOUS BLOOD AND PERIPHERAL BLOOD OF PRIMATES. J Physiol. 1963 Nov;169:330–338. doi: 10.1113/jphysiol.1963.sp007259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FREDRICKSON D. S., GORDON R. S., Jr Transport of fatty acids. Physiol Rev. 1958 Oct;38(4):585–630. doi: 10.1152/physrev.1958.38.4.585. [DOI] [PubMed] [Google Scholar]
- FROESCH E. R., REARDON J. B., RENOLD A. E. The determination of inulin in blood and urine using glucose oxidase for the removal of interfering glucose. J Lab Clin Med. 1957 Dec;50(6):918–921. [PubMed] [Google Scholar]
- MAHON W. A., STEINKE J., McKHANN G. M., MITCHELL M. L. Measurement of I-131-insulin and of insulin-like activity in cerebrospinal fluid of man. Metabolism. 1962 Apr;11:416–420. [PubMed] [Google Scholar]
- RENOLD A. E., MARTIN D. B., DAGENAIS Y. M., STEINKE J., NICKERSON R. J., SHEPS M. C. Measurement of small quantities of insulin-like activity using rat adipose tissue. I. A proposed procedure. J Clin Invest. 1960 Sep;39:1487–1498. doi: 10.1172/JCI104168. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SAMAAN N., FRASER R., DEMPSTER W. J. THE "TYPICAL" AND "ATYPICAL" FORMS OF SERUM INSULIN. Diabetes. 1963 Jul-Aug;12:339–348. doi: 10.2337/diab.12.4.339. [DOI] [PubMed] [Google Scholar]
- SKINNER S. L., MCCUBBIN J. W., PAGE I. H. ANGIOTENSIN IN BLOOD AND LYMPH FOLLOWING REDUCTION IN RENAL ARTERIAL PERFUSION PRESSURE IN DOGS. Circ Res. 1963 Oct;13:336–345. doi: 10.1161/01.res.13.4.336. [DOI] [PubMed] [Google Scholar]
- Soeldner J. S., Slone D. Critical variables in the radioimmunoassay of serum insulin using the double antibody technic. Diabetes. 1965 Dec;14(12):771–779. doi: 10.2337/diab.14.12.771. [DOI] [PubMed] [Google Scholar]