Abstract
The aim of the study was to compare once-daily with divided dosage lithium treatment in acute mania. In 79 retrospectively studied subjects who met the DSMIII-R criteria for mania, 26 independent and dependent variables were analyzed. The two groups of patients (categorized according to dosage schedule) were broadly comparable with respect to demographic and clinical characteristics. The two groups also did not differ on the outcome measures of lithium efficacy and lithium adverse effects. It is concluded that single dose lithium therapy is clinically comparable with divided dose lithium therapy in acute mania. Possible advantages of switching over to once-daily lithium regimes are discussed.
Keywords: lithium, acute mania
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- Grof P., MacCrimmon D. J., Smith E. K., Daigle L., Saxena B., Varma R., Grof E., Keitner G., Kenny J. Long-term lithium treatment and the kidney. Interim report on fifty patients. Can J Psychiatry. 1980 Nov;25(7):535–544. doi: 10.1177/070674378002500701. [DOI] [PubMed] [Google Scholar]
- Kehoe R. F., Mander A. J. Lithium treatment: prescribing and monitoring habits in hospital and general practice. BMJ. 1992 Feb 29;304(6826):552–554. doi: 10.1136/bmj.304.6826.552. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lauritsen B. J., Mellerup E. T., Plenge P., Rasmussen S., Vestergaard P., Schou M. Serum lithium concentrations around the clock with different treatment regimens and the diurnal variation of the renal lithium clearance. Acta Psychiatr Scand. 1981 Oct;64(4):314–319. doi: 10.1111/j.1600-0447.1981.tb00788.x. [DOI] [PubMed] [Google Scholar]
- Muir A., Davidson R., Silverstone T., Dawnay A., Forsling M. L. Two regimens of lithium prophylaxis and renal function. Acta Psychiatr Scand. 1989 Dec;80(6):579–583. doi: 10.1111/j.1600-0447.1989.tb03029.x. [DOI] [PubMed] [Google Scholar]
- Perry P. J., Dunner F. J., Hahn R. L., Tsuang M. T., Berg M. J. Lithium kinetics in single daily dosing. Acta Psychiatr Scand. 1981 Oct;64(4):281–294. doi: 10.1111/j.1600-0447.1981.tb00785.x. [DOI] [PubMed] [Google Scholar]
- Schou M., Amdisen A., Thomsen K., Vestergaard P., Hetmar O., Mellerup E. T., Plenge P., Rafaelsen O. J. Lithium treatment regimen and renal water handling: the significance of dosage pattern and tablet type examined through comparison of results from two clinics with different treatment regimens. Psychopharmacology (Berl) 1982;77(4):387–390. doi: 10.1007/BF00432777. [DOI] [PubMed] [Google Scholar]