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. 1968 Jan;47(1):1–9. doi: 10.1172/JCI105699

Vascular responses after alpha adrenergic receptor blockade

I. Responses of capacitance and resistance vessels to norepinephrine in man

Francois M Abboud 1, Phillip G Schmid 1, John W Eckstein 1
PMCID: PMC297142  PMID: 16695931

Abstract

Experiments were done to test the hypothesis that alpha receptor blockers antagonize more effectively venous than arterial responses to norepinephrine in man.

Systemic arterial blood pressure, venous pressure in the forearm, blood flow through the forearm, and the volume of the forearm at a venous pressure of 30 mm Hg were measured using pressure transducers and a mercury strain-gauge plethysmograph. Infusions of norepinephrine into the brachial artery reduced forearm blood flow and venous distensibility without changing arterial pressure. After intraarterial infusion of phentolamine the decrease in venous distensibility during administration of norepinephrine was blocked almost completely whereas the decrease in blood flow through the forearm was not altered.

The results indicate that alpha adrenergic receptor blockade can antagonize constriction of capacitance vessels more effectively than constriction of resistance vessels.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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