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. 1968 Mar;47(3):458–465. doi: 10.1172/JCI105742

Kinetics of thrombopoiesis

Laurence A Harker 1
PMCID: PMC297192  PMID: 5637135

Abstract

Measurements of megakaryocyte number, volume, nuclear number, and cytoplasmic granulation were compared in animals with induced thrombocytosis, normal platelet counts, and induced thrombocytopenia for 4- and 10-day periods. Thrombopoiesis, as measured by megakaryocytic mass and 35S incorporation into platelets, appeared to be regulated by the demand for circulating platelets. In addition, two mechanisms were operative in the alteration of thrombopoiesis. The first mechanism involved the regulation of endomitosis in the immature megakaryocytes which in turn determined the subsequent volume of platelet-producing cytoplasm. The second mechanism regulated the number of megakaryocytes formed from the precursor, “stem cell,” compartment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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