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. 1968 Apr;47(4):934–939. doi: 10.1172/JCI105785

Circadian periodicity of tryptophan metabolism

Morton I Rapoport 1,2, William R Beisel 1,2
PMCID: PMC297241  PMID: 5641628

Abstract

Rhythmicity of tryptophan metabolism via the kynurenine pathway has been demonstrated in man. Normal subjects given 3 g of tryptophan at 0900 hours excreted almost three times the quantity of kynurenine, kynurenic acid, and xanthurenic acid than did subjects given the same dose at 2100 hours. Other metabolites of the kynurenine pathway varied in the same fashion but with lesser magnitude. In contrast, indican, a tryptophan metabolite not in the kynurenine pathway, varied inversely with the other metabolites measured. The data suggest that the liver enzyme tryptophan pyrrolase has a circadian rhythm in man similar to that already described in mice in a previous study.

Tryptophan tolerance tests in the future should be controlled relative to time of amino acid administration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Altman K., Greengard O. Correlation of kynurenine excretion with liver tryptophan pyrrolase levels in disease and after hydrocortisone induction. J Clin Invest. 1966 Oct;45(10):1527–1534. doi: 10.1172/JCI105459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BERRY L. J., SMYTHE D. S. EFFECTS OF BACTERIAL ENDOTOXINS ON METABOLISM. VI. THE ROLE OF TRYPTOPHAN PYRROLASE IN RESPONSE OF MICE TO ENDOTOXIN. J Exp Med. 1963 Oct 1;118:587–603. doi: 10.1084/jem.118.4.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FEIGELSON P., GREENGARD O. The activation and induction of tryptophan pyrrolase during experimental porphyria and by amino-triazole. Biochim Biophys Acta. 1961 Sep 30;52:509–516. doi: 10.1016/0006-3002(61)90409-7. [DOI] [PubMed] [Google Scholar]
  4. Feigin R. D., Klainer A. S., Beisel W. R. Circadian periodicity of blood amino-acids in adult men. Nature. 1967 Jul 29;215(5100):512–514. doi: 10.1038/215512b0. [DOI] [PubMed] [Google Scholar]
  5. GREENGARD O., FEIGELSON P. The activation and induction of rat liver tryptophan pyrrolase in vivo by its substrate. J Biol Chem. 1961 Jan;236:158–161. [PubMed] [Google Scholar]
  6. HARVEY R. B., BROTHERS A. J. Renal extraction of para-aminohippurate and creatinine measured by continuous in vivo sampling of arterial and renal-vein blood. Ann N Y Acad Sci. 1962 Oct 31;102:46–54. doi: 10.1111/j.1749-6632.1962.tb13624.x. [DOI] [PubMed] [Google Scholar]
  7. KNOX W. E., AUERBACH V. H. The hormonal control of tryptophan peroxidase in the rat. J Biol Chem. 1955 May;214(1):307–313. [PubMed] [Google Scholar]
  8. MICHAEL A. F., DRUMMOND K. N., DOEDEN D., ANDERSON J. A., GOOD R. A. TRYPTOPHAN METABOLISM IN MAN. J Clin Invest. 1964 Sep;43:1730–1746. doi: 10.1172/JCI105048. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. PRICE J. M. Some effects of chelating agents on tryptophan metabolism in man. Fed Proc. 1961 Sep;20(3):223–226. [PubMed] [Google Scholar]
  10. Price J. M., Brown R. R., Yess N. Testing the functional capacity of the tryptophan-niacin pathway in man by analysis of urinary metabolites. Adv Metab Disord. 1965;2:159–225. doi: 10.1016/b978-1-4831-6750-3.50009-3. [DOI] [PubMed] [Google Scholar]
  11. Rapoport M. I., Feigin R. D., Bruton J., Beisel W. R. Circadian rhythm for tryptophan pyrrolase activity and its circulating substrate. Science. 1966 Sep 30;153(3744):1642–1644. doi: 10.1126/science.153.3744.1642. [DOI] [PubMed] [Google Scholar]
  12. Rose D. P. The influence of oestrogens on tryptophan metabolism in man. Clin Sci. 1966 Oct;31(2):265–272. [PubMed] [Google Scholar]
  13. Shambaugh G. E., 3rd, Warner D. A., Beisel W. R. Hormonal factors altering rhythmicity of tyrosine-alpha-ketoglutarate transaminase in rat liver. Endocrinology. 1967 Oct;81(4):811–818. doi: 10.1210/endo-81-4-811. [DOI] [PubMed] [Google Scholar]
  14. WEISSBACH H., KING W., SJOERDSMA A., UDENFRIEND S. Formation of indole-3-acetic acid and tryptamine in animals: a method for estimation of indole-3-acetic acid in tissues. J Biol Chem. 1959 Jan;234(1):81–86. [PubMed] [Google Scholar]
  15. Wurtman R. J., Axelrod J. Daily rhythmic changes in tyrosine transaminase activity of the rat liver. Proc Natl Acad Sci U S A. 1967 Jun;57(6):1594–1598. doi: 10.1073/pnas.57.6.1594. [DOI] [PMC free article] [PubMed] [Google Scholar]

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