Abstract
The regional distribution of pulmonary ventilation and perfusion and regional alveolar ventilation/perfusion ratios were measured with radioactive xenon (133xenon) in 10 patients with asthma in remission. Four subjects had normal ventilation distribution, four had hypoventilation in some regions and normal ventilation in others, and two patients had abnormal ventilation in almost all lung regions. The lung bases were involved most frequently and the middle zones least frequently. Correlation was good between the degree of over-all ventilatory impairment calculated from 133xenon values and measurement of the maximal midexpiratory flow rate the same day.
Regions which were hypoventilated had low ventilation/perfusion ratios and also tended to be hypoperfused. In the eight subjects who had been studied similarly 5 yr previously, changes in regional function correlated in general with changes in over-all function.
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Selected References
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- Anthonisen N. R., Dolovich M. B., Bates D. V. Steady state measurement of regional ventilation to perfusion ratios in normal man. J Clin Invest. 1966 Aug;45(8):1349–1356. doi: 10.1172/JCI105442. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BALL W. C., Jr, STEWART P. B., NEWSHAM L. G., BATES D. V. Regional pulmonary function studied with xenon 133. J Clin Invest. 1962 Mar;41:519–531. doi: 10.1172/JCI104505. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BEALE H. D., FOWLER W. S., COMROE J. H., Jr Pulmonary function studies in 20 asthmatic patients in the symptom-free interval. J Allergy. 1952 Jan;23(1):1–10. doi: 10.1016/0021-8707(52)90067-1. [DOI] [PubMed] [Google Scholar]
- BENTIVOGLIO L. G., BEEREL F., BRYAN A. C., STEWART P. B., ROSE B., BATES D. V. REGIONAL PULMONARY FUNCTION STUDIED WITH XENON IN PATIENTS WITH BRONCHIAL ASTHMA. J Clin Invest. 1963 Aug;42:1193–1200. doi: 10.1172/JCI104805. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bass H., Heckscher T., Anthonisen N. R. Regional pulmonary gas exchange in patients with pulmonary embolism. Clin Sci. 1967 Oct;33(2):355–364. [PubMed] [Google Scholar]
- FISHMAN A. P. Respiratory gases in the regulation of the pulmonary circulation. Physiol Rev. 1961 Jan;41:214–280. doi: 10.1152/physrev.1961.41.1.214. [DOI] [PubMed] [Google Scholar]
- LEDBETTER M. K., BRUCK E., FARHI L. E. PERFUSION OF THE UNDERVENTILATED COMPARTMENT OF THE LUNGS IN ASTHMATIC CHILDREN. J Clin Invest. 1964 Dec;43:2233–2240. doi: 10.1172/JCI105097. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LENFANT C. MEASUREMENT OF VENTILATION/PERFUSION DISTRIBUTION WITH ALVEOLAR-ARTERIAL DIFFERENCES. J Appl Physiol. 1963 Nov;18:1090–1094. doi: 10.1152/jappl.1963.18.6.1090. [DOI] [PubMed] [Google Scholar]
- MATTHEWS C. M., DOLLERY C. T. INTERPRETATION OF 133XE LUNG WASH-IN AND WASH-OUT CURVES USING AND ANALOGUE COMPUTER. Clin Sci. 1965 Jun;28:573–590. [PubMed] [Google Scholar]
- Stead E. A., Warren J. V., Merrill A. J., Brannon E. S. THE CARDIAC OUTPUT IN MALE SUBJECTS AS MEASURED BY THE TECHNIQUE OF RIGHT ATRIAL CATHETERIZATION. NORMAL VALUES WITH OBSERVATIONS ON THE EFFECT OF ANXIETY AND TILTING. J Clin Invest. 1945 May;24(3):326–331. doi: 10.1172/JCI101609. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woolcock A. J., McRae J., Morris J. G., Read J. Abnormal pulmonary blood flow distribution in bronchial asthma. Australas Ann Med. 1966 Aug;15(3):196–203. [PubMed] [Google Scholar]
- Yeh S. Y., Peterson R. E. Solubility of krypton and xenon in blood, protein solutions, and tissue homogenates. J Appl Physiol. 1965 Sep;20(5):1041–1047. doi: 10.1152/jappl.1965.20.5.1041. [DOI] [PubMed] [Google Scholar]