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. 1968 May;47(5):1109–1120. doi: 10.1172/JCI105800

Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis

Anti-γ-globulin factors and their interaction with specific opsonins

Ronald P Messner 1,2, Throstur Laxdal 1,2, Paul G Quie 1,2, Ralph C Williams Jr 1,2
PMCID: PMC297263  PMID: 5645856

Abstract

The effect of anti-γ-globulin factors on 7S γ-globulin opsonins from patients with subacute bacterial endocarditis has been examined with a quantitative in vitro phagocytosis system. Human anti-γ-globulin factors from patients with subacute bacterial endocarditis and rheumatoid arthritis inhibited the opsonic action of 7S γ-globulin specifically bound to bacteria. A similar antiopsonic effect was obtained with rabbit antiserum to human γG globulin. The antiopsonic effect of anti-γ-globulin factors did not correlate with their ability to potentiate agglutination of bacteria by 7S antibody. Competition was demonstrated between the antiopsonic effect of anti-γ-globulin factors and the phagocytosis-promoting action of heat-labile serum factors containing hemolytically active complement.

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Selected References

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