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. Author manuscript; available in PMC: 2010 Nov 4.
Published in final edited form as: Biomaterials. 2009 Dec 22;31(8):2399–2407. doi: 10.1016/j.biomaterials.2009.11.108

Fig. 5.

Fig. 5

The MMP inhibitors have the potential to significantly alter the expression of fibrotic markers. A) Treatment of the cells with TGFβ2 results in a significant increase in the expression of α-smooth muscle actin. However, presumably due to the relatively high basal production of this marker, only MMP 2/9 Inhibitor II was found to decrease expression in FHL 124 cells. Both inhibitors tested resulted in a significant reduction in expression in the B3 cells. B) The inhibitors were also able to reduce the amount of collagen I/III produced by B3 HLE in vitro after 48 h exposure to both drugs and TGFβ2. While TGFβ2 is capable of increasing the amount of collagen production, as expected, co-treatment with MMPIs reduce the amount of collagen even in comparison to untreated controls. Error bars represent standard deviation. * Indicates p < 0.0008; ○ indicates p < 0.009; • indicates p < 0.05.