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. 1968 May;47(5):1221–1229. doi: 10.1172/JCI105811

Arterial wall metabolism in experimental hypertension of coarctation of the aorta of short duration

William Hollander 1,2, Dieter M Kramsch 1,2, Melvin Farmelant 1,2, Irving M Madoff 1,2
PMCID: PMC297274  PMID: 5645864

Abstract

Coarctation of the mid-thoracic aorata was surgically produced in mongrel dogs which were sacrificed from 4-12 wk after the operation. As compared to the findings in control animals, the sodium, chloride, and water content of the hypetensive portion of the coarcted thoracic aorta was significantly elevated, whereas the electrolyte and water content of the relatively normotensive portion of the coarcted aorta was normal. The sodium, potassium, and water content of the pulmonary artery, skeletal muscle, and cardiac muscle of the coarcted dog was not altered. These observations suggest that an elevated arterial pressure may influence the electrolyte and water composition of the arteries.

The arterial pressure also may influence the content and synthesis of acid mucopolysaccharides (MPS) in the arteries since the content of sulfated MPS and the incorporation of injected radiosulfate into sulfated MPS were significantly increased in the hypertensive portion of the coarcted thoracic aorta but were significantly reduced in the relatively normotensive (“hypotensive”) portion of the coarcted aorta. The observed increase in MPS may have been a factor directly responsible for the increase in the sodium content of the hypertensive aorta since MPS can act as polyelectrolytes and bind cations.

Although the arterial pressure may influence certain metabolic functions in the arteries, it did not appear to have a direct effect on the arterial lipids since the lipid content of the hypertensive and of the relatively normotensive portions of the coarcted aorta were comparable to the values found in the normal aorta.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALDRICH B. I. The effects of the hyaluronic acid complex on the distribution of ions. Biochem J. 1958 Oct;70(2):236–244. doi: 10.1042/bj0700236. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BOAS N. F. Method for the determination of hexosamines in tissues. J Biol Chem. 1953 Oct;204(2):553–563. [PubMed] [Google Scholar]
  3. DEMING Q. B., HODES M. E., BALTAZAR A., EDREIRA J. G., TOROSDAG S. The changes in concentration of cholesterol in the serum of hypertensive patients during antihypertensive therapy. Am J Med. 1958 Jun;24(6):882–892. doi: 10.1016/0002-9343(58)90341-3. [DOI] [PubMed] [Google Scholar]
  4. FARBER S. J., SCHUBERT M., SCHUSTER N. The binding of cations by chondroitin sulfate. J Clin Invest. 1957 Dec;36(12):1715–1722. doi: 10.1172/JCI103573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
  6. FRIEDMAN S. M., FRIEDMAN C. L. IONIC BASIS OF VASCULAR RESPONSE TO VASOACTIVE SUBSTANCES. Can Med Assoc J. 1964 Jan 25;90:167–173. [PMC free article] [PubMed] [Google Scholar]
  7. HAUSS W. H., JUNGE-HUELSING G., HOLLANDER H. J. Changes in metabolism of connective tissue associated with ageing and arterio- or atherosclerosis. J Atheroscler Res. 1962 Jan-Apr;2:50–61. doi: 10.1016/s0368-1319(62)80052-0. [DOI] [PubMed] [Google Scholar]
  8. HEADINGS V. E., RONDELL P. A., BOHR D. F. Bound soduium in arterv wall. Am J Physiol. 1960 Nov;199:783–787. doi: 10.1152/ajplegacy.1960.199.5.783. [DOI] [PubMed] [Google Scholar]
  9. HOKIN L. E., HOKIN M. R. Phosphatidic acid metabolism and active transport of sodium. Fed Proc. 1963 Jan-Feb;22:8–18. [PubMed] [Google Scholar]
  10. HOLLANDER W., JUDSON W. E. Electrolyte and water excretion in arterial hypertension. I. Studies in non-medically treated subjects with essential hypertension. J Clin Invest. 1957 Oct;36(10):1460–1469. doi: 10.1172/JCI103543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. HOLLANDER W., JUDSON W. E. Electrolyte and water excretion in arterial hypertension. II. Studies in subjects with essential hypertension after antihypertensive drug treatment. Circulation. 1958 Apr;17(4 Pt 1):576–582. doi: 10.1161/01.cir.17.4.576. [DOI] [PubMed] [Google Scholar]
  12. JONES A. W., FEIGL E. O., PETERSON L. H. WATER AND ELECTROLYTE CONTENT OF NORMAL AND HYPERTENSIVE ARTERIES IN DOGS. Circ Res. 1964 Nov;15:386–392. [PubMed] [Google Scholar]
  13. KAPLAN D., MEYER K. The fate of injected mucopolysac-charides. J Clin Invest. 1962 Apr;41:743–749. doi: 10.1172/JCI104532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. KOLETSKY S., RESNICK H., BEHRIN D. Mesenteric artery electrolytes in experimental hypertension. Proc Soc Exp Biol Med. 1959 Oct;102:12–15. [PubMed] [Google Scholar]
  15. KULONEN E. On the relation of hyaluronic acid to the water and electrolyte metabolism. Acta Physiol Scand. 1952;27(1):82–90. doi: 10.1111/j.1748-1716.1953.tb00925.x. [DOI] [PubMed] [Google Scholar]
  16. LOEVINGER R., BERMAN M. Efficiency criteria in radioactivity counting. Nucleonics. 1951 Jul;9(1):26–39. [PubMed] [Google Scholar]
  17. LOWRY O. H., ROBERTS N. R., LEINER K. Y., WU M. L., FARR A. L. The quantitative histochemistry of brain. I. Chemical methods. J Biol Chem. 1954 Mar;207(1):1–17. [PubMed] [Google Scholar]
  18. MILLER E., HLAD C. J., Jr, LEVINE S., HOLMES J. H., ELRICK H. The use of radioisotopes to measure body fluid constituents. I. Plasma sulfate. J Lab Clin Med. 1961 Oct;58:656–661. [PubMed] [Google Scholar]
  19. PERRY H. M., Jr, SCHROEDER H. A. Depression of cholesterol levels in human plasma following ethylenediamine tetracetate and hydralazine. J Chronic Dis. 1955 Nov;2(5):520–533. doi: 10.1016/0021-9681(55)90151-x. [DOI] [PubMed] [Google Scholar]
  20. SHACK J., JENKINS R. J., THOMPSETT J. M. The interaction of ions and desoxypentose nucleic acid of calf thymus. J Biol Chem. 1953 Jul;203(1):373–387. [PubMed] [Google Scholar]
  21. SIREK O. V., SCHILLER S., DORFMAN A. ACID MUCOPOLYSACCHARIDES IN AORTIC TISSUE OF THE DOG. Biochim Biophys Acta. 1964 Jul 7;83:148–151. doi: 10.1016/0926-6526(64)90030-8. [DOI] [PubMed] [Google Scholar]
  22. TOBIAN L., FOX A. The effect of norepinephrine on the electrolyte composition of arterial smooth muscle. J Clin Invest. 1956 Mar;35(3):297–301. doi: 10.1172/JCI103277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. TOBIAN L., Jr, BINION J. T. Tissue cations and water in arterial hypertension. Circulation. 1952 May;5(5):754–758. doi: 10.1161/01.cir.5.5.754. [DOI] [PubMed] [Google Scholar]
  24. TOBIAN L., Jr, BINION J. Artery wall electrolytes in renal and DCA hypertension. J Clin Invest. 1954 Oct;33(10):1407–1414. doi: 10.1172/JCI103018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. TOBIAN L., REDLEAF P. D. Ionic composition of the aorta in renal and adrenal hypertension. Am J Physiol. 1958 Feb;192(2):325–330. doi: 10.1152/ajplegacy.1958.192.2.325. [DOI] [PubMed] [Google Scholar]
  26. VAN HANDEL E., ZILVERSMIT D. B. Micromethod for the direct determination of serum triglycerides. J Lab Clin Med. 1957 Jul;50(1):152–157. [PubMed] [Google Scholar]
  27. WILSON R. B., CLARKE T. J. INDIRECT MEASUREMENT OF SYSTOLIC BLOOD PRESSURE IN DOGS BY THE USE OF A XYLOL PULSE INDICATOR. J Am Vet Med Assoc. 1964 May 1;144:981–984. [PubMed] [Google Scholar]

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