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. 1968 Jul;47(7):1627–1639. doi: 10.1172/JCI105854

The red cell mass-arterial oxygen relationship in normal man

Application to patients with chronic obstructive airway disease

John V Weil 1, Gail Jamieson 1, Donald W Brown 1, Robert F Grover 1
PMCID: PMC297320  PMID: 5658592

Abstract

The normal relationship between red cell mass measured, with 51chromium-labeled red cells, and arterial oxygen saturation (SaO2) over the range from 97.3 to 83.4% was examined by studying 73 normal men residing at sea level and altitudes of 1600 and 3100 m. A simple, linear relationship between SaO2 and red cell mass was found over the entire range (r = - 0.7524, P < 0.001). In contrast, a correlation between red cell mass and arterial O2 tension was found only over the lower half of the range of O2 tensions where SaO2 was also decreased (r = - 0.7731, P < 0.005). This suggested that O2 saturation rather than tension is the more important determinant of the erythropoietic response to chronic hypoxia. If this response is regulated by tissue O2 tension, then it will be influenced by O2 transport, which, in turn, is a function of blood flow and arterial O2 content, and hence SaO2. In nine patients with chronic obstructive airway disease the relationship between red cell mass and SaO2 was also determined and was found to be steeper than in the normal subjects (P < 0.05).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSEN S. B., GABUZDA T. G. SIMULTANEOUS DETERMINATION OF PLASMA VOLUME WITH T-1824 AND 131-I-LABELLED AUTOLOGOUS AND HOMOLOGOUS PARAPROTEIN. Clin Sci. 1964 Feb;26:41–45. [PubMed] [Google Scholar]
  2. BAKER R. J., KOZOLL D. D., MEYER K. A. The use of surface area as a basis for establishing normal blood volume. Surg Gynecol Obstet. 1957 Feb;104(2):183–189. [PubMed] [Google Scholar]
  3. BERLIN N. I., LAWRENCE J. H., GARTLAND J. Blood volume in polycythemia as determined by P32 labeled red blood cells. Am J Med. 1950 Dec;9(6):747–751. doi: 10.1016/0002-9343(50)90289-0. [DOI] [PubMed] [Google Scholar]
  4. Benesch R., Benesch R. E. The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin. Biochem Biophys Res Commun. 1967 Jan 23;26(2):162–167. doi: 10.1016/0006-291x(67)90228-8. [DOI] [PubMed] [Google Scholar]
  5. Boyd G. W. The reproducibility and accuracy of plasma volume estimation in the sheep with both 131I gamma globulin and Evan's blue. Aust J Exp Biol Med Sci. 1967 Feb;45(1):51–75. doi: 10.1038/icb.1967.3. [DOI] [PubMed] [Google Scholar]
  6. Burrows B., Fletcher C. M., Heard B. E., Jones N. L., Wootliff J. S. The emphysematous and bronchial types of chronic airways obstruction. A clinicopathological study of patients in London and Chicago. Lancet. 1966 Apr 16;1(7442):830–835. doi: 10.1016/s0140-6736(66)90181-4. [DOI] [PubMed] [Google Scholar]
  7. DORNHORST A. C. Respiratory insufficiency. Lancet. 1955 Jun 11;268(6876):1185–1187. [PubMed] [Google Scholar]
  8. EISENBERG S. The effect of congestive heart failure on blood volume as determined by radiochromium-tagged red cells. Circulation. 1954 Dec;10(6):902–911. doi: 10.1161/01.cir.10.6.902. [DOI] [PubMed] [Google Scholar]
  9. FRIED W., GOLDWASSER E., JACOBSON L. O., PLZAK L. F. Studies on erythropoiesis. III. Factors controlling erythropoietin production. Proc Soc Exp Biol Med. 1957 Jan;94(1):237–241. doi: 10.3181/00379727-94-22910. [DOI] [PubMed] [Google Scholar]
  10. GARBY L., VUILLE J. C. The amount of trapped plasma in a high speed micro-capillary hematocrit centrifuge. Scand J Clin Lab Invest. 1961;13:642–645. doi: 10.3109/00365516109137338. [DOI] [PubMed] [Google Scholar]
  11. GREGERSEN M. I., RAWSON R. A. Blood volume. Physiol Rev. 1959 Apr;39(2):307–342. doi: 10.1152/physrev.1959.39.2.307. [DOI] [PubMed] [Google Scholar]
  12. HUFF R. L., FELLER D. D. Relation of circulating red cell volume to body density and obesity. J Clin Invest. 1956 Jan;35(1):1–10. doi: 10.1172/JCI103242. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. HUFF R. L., LAWRENCE J. H., SIRI W. E., WASSERMAN L. R., HENNESSY T. G. Effects of changes in altitude on hematopoietic activity. Medicine (Baltimore) 1951 Sep;30(3):197–217. doi: 10.1097/00005792-195109000-00001. [DOI] [PubMed] [Google Scholar]
  14. HUME R., GOLDBERG A. ACTUAL AND PREDICTED-NORMAL RED-CELL AND PLASMA VOLUMES IN PRIMARY AND SECONDARY POLYCYTHAEMIA. Clin Sci. 1964 Jun;26:499–508. [PubMed] [Google Scholar]
  15. LERTZMAN M., FROME B. M., ISRAELS L. G., CHERNIACK R. M. HYPOXIA IN POLYCYTHEMIA VERA. Ann Intern Med. 1964 Mar;60:409–417. doi: 10.7326/0003-4819-60-3-409. [DOI] [PubMed] [Google Scholar]
  16. MERINO C. F. Studies on blood formation and destruction in the polycythemia of high altitude. Blood. 1950 Jan;5(1):1–31. [PubMed] [Google Scholar]
  17. MOLLISON P. L., VEALL N. The use of the isotope 51Cr as a label for red cells. Br J Haematol. 1955 Jan;1(1):62–74. doi: 10.1111/j.1365-2141.1955.tb05489.x. [DOI] [PubMed] [Google Scholar]
  18. NOMOF N., HOPPER J., Jr, BROWN E., SCOTT K., WENNESLAND R. Simultaneous determinations of the total volume of red blood cells by use of carbon monoxide and chromium in healthy and diseased human subjects. J Clin Invest. 1954 Oct;33(10):1382–1387. doi: 10.1172/JCI103015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Okin J. T., Treger A., Overy H. R., Weil J. V., Grover R. F. Hematologic response to medium altitude. Rocky Mt Med J. 1966 Jan;63(1):44–47. [PubMed] [Google Scholar]
  20. RATTO O., BRISCOE W. A., MORTON J. W., COMROE J. H., Jr Anoxemia secondary to polycythemia and polycythemia secondary to anoxemia. Am J Med. 1955 Dec;19(6):958–965. doi: 10.1016/0002-9343(55)90162-5. [DOI] [PubMed] [Google Scholar]
  21. REYNAFARJE C., LOZANO R., VALDIVIESO J. The polycythemia of high altitudes: iron metabolism and related aspects. Blood. 1959 Apr;14(4):433–455. [PubMed] [Google Scholar]
  22. Severinghaus J. W. Blood gas calculator. J Appl Physiol. 1966 May;21(3):1108–1116. doi: 10.1152/jappl.1966.21.3.1108. [DOI] [PubMed] [Google Scholar]
  23. VANIER T., DULFANO J., WU C., DESFORGES J. F. Emphysema, hypoxia and the polycthemic response. N Engl J Med. 1963 Jul 25;269:169–178. doi: 10.1056/NEJM196307252690401. [DOI] [PubMed] [Google Scholar]
  24. VEREL D. Blood volume changes in cyanotic congenital heart disease and polycythemia rubra vera. Circulation. 1961 May;23:749–753. doi: 10.1161/01.cir.23.5.749. [DOI] [PubMed] [Google Scholar]
  25. WENNESLAND R., BROWN E., HOPPER J., Jr, HODGES J. L., Jr, GUTTENTAG O. E., SCOTT K. G., TUCKER I. N., BRADLEY B. Red cell, plasma and blood volume in healthy men measured by radiochromium (Cr51) cell tagging and hematocrit: influence of age, somatotype and habits of physical activity on the variance after regression of volumes to height and weight combined. J Clin Invest. 1959 Jul;38(7):1065–1077. doi: 10.1172/JCI103883. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. WILLIAMS J. A., FINE J. Measurement of blood volume with a new apparatus. N Engl J Med. 1961 Apr 27;264:842–848. doi: 10.1056/NEJM196104272641702. [DOI] [PubMed] [Google Scholar]
  27. WILSON R. H., BORDEN C. W., EBERT R. V. Adaptation to anoxia in chronic pulmonary emphysema. AMA Arch Intern Med. 1951 Nov;88(5):581–590. doi: 10.1001/archinte.1951.03810110033003. [DOI] [PubMed] [Google Scholar]

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